Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011080-04
Application #
2052293
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1993-04-15
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Sell, D R; Nelson, J F; Monnier, V M (2001) Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat. J Gerontol A Biol Sci Med Sci 56:B405-11
Sell, D R; Kleinman, N R; Monnier, V M (2000) Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice. FASEB J 14:145-56
Monnier, V M; Bautista, O; Kenny, D et al. (1999) Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Co Diabetes 48:870-80
Sell, D R; Primc, M; Schafer, I A et al. (1998) Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo. Mech Ageing Dev 105:221-40
Sell, D R; Monnier, V M (1997) Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs C57BL/6 mice: the effect of dietary restriction. J Gerontol A Biol Sci Med Sci 52:B277-84
Sell, D R (1997) Ageing promotes the increase of early glycation Amadori product as assessed by epsilon-N-(2-furoylmethyl)-L-lysine (furosine) levels in rodent skin collagen. The relationship to dietary restriction and glycoxidation. Mech Ageing Dev 95:81-99
Sell, D R; Lane, M A; Johnson, W A et al. (1996) Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc Natl Acad Sci U S A 93:485-90