Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011119-04
Application #
2052331
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1993-03-01
Project End
1997-02-28
Budget Start
1996-03-06
Budget End
1997-02-28
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E et al. (2017) Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. Cell Rep 18:2310-2319
Williams, Eric O; Taylor, Amy K; Bell, Eric L et al. (2016) Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. Cell Rep 17:809-820
Herskovits, A Zara; Guarente, Leonard (2014) SIRT1 in neurodevelopment and brain senescence. Neuron 81:471-83
Li, Yu; Wong, Kimberly; Giles, Amber et al. (2014) Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology 146:539-49.e7
Bell, Eric L; Nagamori, Ippei; Williams, Eric O et al. (2014) SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development 141:3495-504
Imai, Shin-ichiro; Guarente, Leonard (2014) NAD+ and sirtuins in aging and disease. Trends Cell Biol 24:464-71
Chang, Hung-Chun; Guarente, Leonard (2014) SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab 25:138-45
Simic, Petra; Williams, Eric O; Bell, Eric L et al. (2013) SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Rep 3:1175-86
Hasegawa, Kazuhiro; Wakino, Shu; Simic, Petra et al. (2013) Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med 19:1496-504
Chang, Hung-Chun; Guarente, Leonard (2013) SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153:1448-60

Showing the most recent 10 out of 31 publications