Established in 1994, the Cache County Study is a population-based longitudinal investigation of dementia in relation to genetic and environmental antecedents. The renewal of this important work will capitalize on nine years of prospective observation in this epidemiological cohort and will have available longitudinal cognitive assessments in the entire sample. Using these observations, we will empirically define the early cognitive trajectory of preclinical Alzheimer's disease (AD) and the relationship of antecedent exposures to the rate of decline and to categorical outcomes of dementia. There are four major specific aims of the project, which are as follows: 1. Conduct two more triennial waves of screening (Waves 3 and 4) among Cache County residents not demented at prior screenings. Use the nine years of observation to examine the trajectory of cognitive change to dementia and to obtain more precise estimates of the incidence of AD, especially after age 85. 2. Use an expanded cognitive screening battery for proposed Waves 3 and 4. Examine the efficiency of the new battery as a screen for dementia. Also, use the resulting expanded information base to extend existing data on trajectory of cognitive functioning to a nine-year time interval. With this new information, examine: a) Individual (cross sectional) features of cognitive dysfunction, or clusters of such features, that most strongly predict subsequent development of dementia; b) Nature and extent of change in such features or their clusters over time, including specifically a search for changes that most strongly predict the development of dementia; c) Various operationally defined categories of cognitive impairment (e.g., """"""""Mild Cognitive Impairment"""""""" [MCI], etc.) and compare their abilities to predict subsequent dementia. 3. Extend prior studies of the influence of genetic and environmental factors on risk of AD, noting whether these same factors predict tragectory of cognitive decline as a prodrome of AD. 4. Continue and extend the study's existing autopsy program, expanding its aims to clinically diagnosed dementia subtypes and to unaffected participants, particularly those with risk factors for dementia (age 85+, MCI).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG011380-09
Application #
6473916
Study Section
Special Emphasis Panel (ZRG1-EDC-3 (01))
Program Officer
Anderson, Dallas
Project Start
1994-09-30
Project End
2007-03-31
Budget Start
2002-07-15
Budget End
2003-03-31
Support Year
9
Fiscal Year
2002
Total Cost
$2,044,076
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Sanders, Chelsea; Behrens, Stephanie; Schwartz, Sarah et al. (2016) Nutritional Status is Associated with Faster Cognitive Decline and Worse Functional Impairment in the Progression of Dementia: The Cache County Dementia Progression Study1. J Alzheimers Dis 52:33-42
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Peters, Matthew E; Schwartz, Sarah; Han, Dingfen et al. (2015) Neuropsychiatric symptoms as predictors of progression to severe Alzheimer's dementia and death: the Cache County Dementia Progression Study. Am J Psychiatry 172:460-5
Rattinger, Gail B; Schwartz, Sarah; Mullins, C Daniel et al. (2015) Dementia severity and the longitudinal costs of informal care in the Cache County population. Alzheimers Dement 11:946-54
Snyder, Christine M; Fauth, Elizabeth; Wanzek, Joseph et al. (2015) Dementia caregivers' coping strategies and their relationship to health and well-being: the Cache County Study. Aging Ment Health 19:390-9

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