Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011491-08
Application #
6629794
Study Section
Cardiovascular and Renal Study Section (CVB)
Program Officer
Kohanski, Ronald A
Project Start
2001-03-01
Project End
2005-02-28
Budget Start
2003-03-15
Budget End
2004-02-29
Support Year
8
Fiscal Year
2003
Total Cost
$278,250
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Physiology
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Dobson Jr, James G; Shea, Lynne G; Fenton, Richard A (2008) Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 295:H2364-72
Tikh, Eugene I; Fenton, Richard A; Chen, Jiang-Fan et al. (2008) Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart. J Cell Physiol 216:83-90
Fenton, Richard A; Dobson Jr, James G (2007) Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes. J Cell Physiol 213:785-92
Tikh, Eugene I; Fenton, Richard A; Dobson Jr, James G (2006) Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts. Am J Physiol Heart Circ Physiol 290:H348-56
Fenton, Richard A; Dickson, Eric W; Dobson Jr, James G (2005) Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci 77:3375-88
Miyazaki, Koji; Komatsu, Satoshi; Ikebe, Mitsuo et al. (2004) Protein kinase Cepsilon and the antiadrenergic action of adenosine in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 287:H1721-9
Lorbar, Mojca; Chung, Eugene S; Nabi, Arash et al. (2004) Receptors subtypes involved in adenosine-mediated modulation of norepinephrine release from cardiac nerve terminals. Can J Physiol Pharmacol 82:1026-31
Dobson Jr, James G; Fray, John; Leonard, Jack L et al. (2003) Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling. Physiol Genomics 15:142-7
Dobson Jr, James G; Shea, Lynne G; Fenton, Richard A (2003) Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation. Am J Physiol Heart Circ Physiol 285:H1471-8
Reisert, Patricia S; Dobson Jr, James G; Fenton, Richard A (2002) Anoxia-induced changes in purine nucleoside metabolism of in vitro aged human fibroblasts. Life Sci 70:1369-82

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