Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011526-05
Application #
2052727
Study Section
Special Emphasis Panel (ZHL1-CSR-J (01))
Project Start
1992-09-30
Project End
1997-06-30
Budget Start
1996-07-20
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Davies, T A; Long, H J; Eisenhauer, P B et al. (2000) Beta amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: usage of a novel blood brain barrier endothelial cell model system. Amyloid 7:153-65
Abraham, C R; Marshall, D C; Tibbles, H E et al. (1999) Platelets and DAMI megakaryocytes possess beta-secretase-like activity. J Lab Clin Med 133:507-15
Simons, E R; Marshall, D C; Long, H J et al. (1998) Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases. Amyloid 5:153-62
Davies, T A; Billingslea, A M; Long, H J et al. (1998) Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein. J Lab Clin Med 132:341-50
Davies, T A; Billingslea, A; Johnson, R et al. (1997) Stimulus responses and amyloid precursor protein processing in DAMI megakaryocytes. J Lab Clin Med 130:21-32
Davies, T A; Long, H J; Tibbles, H E et al. (1997) Moderate and advanced Alzheimer's patients exhibit platelet activation differences. Neurobiol Aging 18:155-62
Davies, T A; Long, H J; Sgro, K et al. (1997) Activated Alzheimer disease platelets retain more beta amyloid precursor protein. Neurobiol Aging 18:147-53
Davies, T A; Fine, R E; Johnson, R J et al. (1993) Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. Biochem Biophys Res Commun 194:537-43