Cloning of the Chromosome 14 Alzheimers Disease Gene

Schellenberg, Gerard David

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Project (R01)
• Project #: 5R01AG011762-03
• Application #: 2052975
• Study Section: Neurology C Study Section (NEUC)
• Project Start: 1994-06-01
• Project End: 1999-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Washington
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 135646524
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Ryman, Davis C; Acosta-Baena, Natalia; Aisen, Paul S et al. (2014) Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology 83:253-60

Melrose, H L; Dächsel, J C; Behrouz, B et al. (2010) Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiol Dis 40:503-17

Kay, D M; Stevens, C F; Hamza, T H et al. (2010) A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2. Neurology 75:1189-94

Choi, Yoonha; Wijsman, Ellen M; Weir, Bruce S (2009) Case-control association testing in the presence of unknown relationships. Genet Epidemiol 33:668-78

Sieh, Weiva; Choi, Yoonha; Chapman, Nicola H et al. (2009) Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates. Hum Mol Genet 18:3725-38

Wijsman, Ellen M; Sung, Yun Ju; Buil, Alfonso et al. (2007) Summary of Genetic Analysis Workshop 15: Group 9 linkage analysis of the CEPH expression data. Genet Epidemiol 31 Suppl 1:S75-85

Sieh, Weiva; Yu, Chang-En; Bird, Thomas D et al. (2007) Accounting for linkage disequilibrium among markers in linkage analysis: impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease. Hum Hered 63:26-34

D'Souza, Ian; Schellenberg, Gerard D (2006) Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279K. J Biol Chem 281:2460-9

Wijsman, Ellen M; Daw, E Warwick; Yu, Xuesong et al. (2005) APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation. Am J Med Genet B Neuropsychiatr Genet 132B:14-20

Wijsman, Ellen M; Daw, E Warwick; Yu, Change-En et al. (2004) Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. Am J Hum Genet 75:398-409