Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG011921-01A2
Application #
2053204
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (02))
Project Start
1996-02-20
Project End
1999-01-31
Budget Start
1996-02-20
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Winifred Masterson Burke Med Research Institute
Department
Type
DUNS #
780676131
City
White Plains
State
NY
Country
United States
Zip Code
10605

  Publications

Gibson, Gary E; Hirsch, Joseph A; Fonzetti, Pasquale et al. (2016) Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci 1367:21-30
Bubber, P; Hartounian, V; Gibson, G E et al. (2011) Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients. Eur Neuropsychopharmacol 21:254-60
Karuppagounder, Saravanan S; Xu, Hui; Shi, Qingli et al. (2009) Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol Aging 30:1587-600
Shi, Qingli; Risa, Øystein; Sonnewald, Ursula et al. (2009) Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J Neurochem 109 Suppl 1:214-21
Gibson, Gary E; Karuppagounder, Saravanan S; Shi, Qingli (2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease. Ann N Y Acad Sci 1147:221-32
Karuppagounder, Saravanan S; Xu, Hui; Pechman, David et al. (2008) Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochem Res 33:1365-72
Shi, Qingli; Xu, Hui; Kleinman, Wayne A et al. (2008) Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta 1782:229-38
Karuppagounder, Saravanan S; Shi, Qingli; Xu, Hui et al. (2007) Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiol Dis 26:353-62
Shi, Q; Karuppagounder, S S; Xu, H et al. (2007) Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. Neurochem Int 50:921-31
Waagepetersen, Helle S; Hansen, Gert H; Fenger, Kirsten et al. (2006) Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase. Glia 53:225-31

Showing the most recent 10 out of 53 publications