Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012028-03
Application #
2053388
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1994-05-12
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Florida
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Tampa
State
FL
Country
United States
Zip Code
33612
Houlden, H; Crook, R; Backhovens, H et al. (1998) ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families. Am J Med Genet 81:117-21
Fox, N C; Kennedy, A M; Harvey, R J et al. (1997) Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor. Brain 120 ( Pt 3):491-501
Wragg, M; Hutton, M; Talbot, C (1996) Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group. Lancet 347:509-12
Hutton, M; Busfield, F; Wragg, M et al. (1996) Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease. Neuroreport 7:801-5
Clark, R F; Hutton, M; Talbot, C et al. (1996) The role of presenilin 1 in the genetics of Alzheimer's disease. Cold Spring Harb Symp Quant Biol 61:551-8
Prihar, G; Fuldner, R A; Perez-Tur, J et al. (1996) Structure and alternative splicing of the presenilin-2 gene. Neuroreport 7:1680-4
Perez-Tur, J; Croxton, R; Wright, K et al. (1996) A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease. Neurodegeneration 5:207-12
Perez-Tur, J; Froelich, S; Prihar, G et al. (1995) A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport 7:297-301
(1995) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Alzheimer's Disease Collaborative Group. Nat Genet 11:219-22