Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012275-03
Application #
2053774
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Finkelstein, David B
Project Start
1994-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Ferrington, Deborah A; Yao, Qing; Squier, Thomas C et al. (2002) Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Biochemistry 41:13289-96
Yao, Q; Chen, L T; Li, J et al. (2001) Oligomeric interactions between phospholamban molecules regulate Ca-ATPase activity in functionally reconstituted membranes. Biochemistry 40:6406-13
Negash, S; Yao, Q; Sun, H et al. (2000) Phospholamban remains associated with the Ca2+- and Mg2+-dependent ATPase following phosphorylation by cAMP-dependent protein kinase. Biochem J 351:195-205
Schoneich, C; Viner, R I; Ferrington, D A et al. (1999) Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat. Mech Ageing Dev 107:221-31
Qin, Z; Zaidi, A; Gao, J et al. (1998) Decrease in Ca-ATPase activity in aged synaptosomal membranes is not associated with changes in fatty acyl chain dynamics. Mech Ageing Dev 105:291-300
Ferrington, D A; Krainev, A G; Bigelow, D J (1998) Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle. J Biol Chem 273:5885-91
Krainev, A G; Williams, T D; Bigelow, D J (1998) Enzymatic reduction of 3-nitrotyrosine generates superoxide. Chem Res Toxicol 11:495-502
Viner, R I; Krainev, A G; Williams, T D et al. (1997) Identification of oxidation-sensitive peptides within the cytoplasmic domain of the sarcoplasmic reticulum Ca2+-ATPase. Biochemistry 36:7706-16
Ferrington, D A; Chen, X; Krainev, A G et al. (1997) Protein half-lives of calmodulin and the plasma membrane Ca-ATPase in rat brain. Biochem Biophys Res Commun 237:163-5
Ferrington, D A; Jones, T E; Qin, Z et al. (1997) Decreased conformational stability of the sarcoplasmic reticulum Ca-ATPase in aged skeletal muscle. Biochim Biophys Acta 1330:233-47

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