Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012287-03
Application #
2053798
Study Section
Endocrinology Study Section (END)
Project Start
1994-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Yuan, Furong; Chen, Meizhen; Hornsby, Peter J (2010) Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis. Oncol Rep 23:377-86
Nakamura, Yasuhiro; Hornsby, Peter J; Casson, Peter et al. (2009) Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis. J Clin Endocrinol Metab 94:2192-8
Liang, Sitai; Kahlenberg, Morton S; Rousseau Jr, Dennis L et al. (2008) Neoplastic conversion of human colon smooth muscle cells: No requirement for telomerase. Mol Carcinog 47:478-84
Hornsby, Peter J (2007) Senescence as an anticancer mechanism. J Clin Oncol 25:1852-7
Liu, Dan; Hornsby, Peter J (2007) Fibroblast stimulation of blood vessel development and cancer cell invasion in a subrenal capsule xenograft model: stress-induced premature senescence does not increase effect. Neoplasia 9:418-26
Casson, Peter R; Buster, John E; Callas, Peter M et al. (2007) Human chorionic gonadotropin does not alter patterns of adrenal androgen secretion in primary human adrenal reticularis and fasciculata cell culture. Menopause 14:316-9
Liu, Dan; Hornsby, Peter J (2007) Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res 67:3117-26
Chen, M; Hornsby, P J (2006) Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells. Horm Metab Res 38:549-55
Hornsby, Peter J (2005) Replicative senescence and cancer. Cancer Treat Res 124:53-73
Sun, Beicheng; Chen, Meizhen; Hawks, Christina L et al. (2005) Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation. Cancer Res 65:6512-5

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