Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012442-02
Application #
2054060
Study Section
Special Emphasis Panel (ZRG3-PTHB (01))
Project Start
1995-04-01
Project End
1999-02-28
Budget Start
1996-03-05
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Biology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
LeDoux, S P; Wilson, G L (2001) Base excision repair of mitochondrial DNA damage in mammalian cells. Prog Nucleic Acid Res Mol Biol 68:273-84
Druzhyna, N; Smulson, M E; LeDoux, S P et al. (2000) Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA. Diabetes 49:1849-55
Grishko, V I; Druzhyna, N; LeDoux, S P et al. (1999) Nitric oxide-induced damage to mtDNA and its subsequent repair. Nucleic Acids Res 27:4510-6
Ledoux, S P; Shen, C C; Grishko, V I et al. (1998) Glial cell-specific differences in response to alkylation damage. Glia 24:304-12
Druzhyna, N; Nair, R G; LeDoux, S P et al. (1998) Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome. Mutat Res 409:81-9
Bozner, P; Grishko, V; LeDoux, S P et al. (1997) The amyloid beta protein induces oxidative damage of mitochondrial DNA. J Neuropathol Exp Neurol 56:1356-62
Wilson, G L; Patton, N J; LeDoux, S P (1997) Mitochondrial DNA in beta-cells is a sensitive target for damage by nitric oxide. Diabetes 46:1291-5
Grishko, V I; Driggers, W J; LeDoux, S P et al. (1997) Repair of oxidative damage in nuclear DNA sequences with different transcriptional activities. Mutat Res 384:73-80
Driggers, W J; Grishko, V I; LeDoux, S P et al. (1996) Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line. Cancer Res 56:1262-6