Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012447-03
Application #
2054069
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1994-08-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Lesnefsky, Edward J; He, DingChao; Moghaddas, Shadi et al. (2006) Reversal of mitochondrial defects before ischemia protects the aged heart. FASEB J 20:1543-5
Schomisch, Steve J; Murdock, Deborah G; Hedayati, Nasim et al. (2005) Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. J Thorac Cardiovasc Surg 130:1151
Lesnefsky, Edward J; Hoppel, Charles L (2003) Ischemia-reperfusion injury in the aged heart: role of mitochondria. Arch Biochem Biophys 420:287-97
Moghaddas, Shadi; Hoppel, Charles L; Lesnefsky, Edward J (2003) Aging defect at the QO site of complex III augments oxyradical production in rat heart interfibrillar mitochondria. Arch Biochem Biophys 414:59-66
Hedayati, Nasim; Schomisch, Steve J; Carino, Joseph L et al. (2003) Cardioprotection by St Thomas' solution is mediated by protein kinase C and tyrosine kinase. J Surg Res 113:121-7
Hoppel, Charles L; Moghaddas, Shadi; Lesnefsky, Edward J (2002) Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart. Biogerontology 3:41-4
Moghaddas, Shadi; Stoll, Maria S K; Minkler, Paul E et al. (2002) Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria. J Gerontol A Biol Sci Med Sci 57:B22-8
Lesnefsky, E J; Moghaddas, S; Tandler, B et al. (2001) Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure. J Mol Cell Cardiol 33:1065-89
Lesnefsky, E J; Gudz, T I; Moghaddas, S et al. (2001) Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site. J Mol Cell Cardiol 33:37-47
Kerner, J; Turkaly, P J; Minkler, P E et al. (2001) Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content. Am J Physiol Endocrinol Metab 281:E1054-62

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