Little is known about the functional benefits of strengthening exercises in older persons. The proposed project will experimentally determine if strengthening exercises for community-dwelling, disabled older men and women result in improvements in gait and other locomotor activities. The experimental plan proposes to study 100 disabled elders randomly assigned to 6 months strengthening exercises or no-exercise control. The general hypothesis is that disabled older persons compensate for strength impairments by substituting potentially destabilizing, quantifiable body postures and movement strategies, and that these compensations are reduced following strength gains. Proposed Specific Aims are: 1) to determine the body segment postures, momentum and compensatory strategies in disabled older persons. It is hypothesized that disabled older persons use excessive upper body momentum to substitute for lower limb weakness during locomotor activities; 2) to assess whether functional abilities improve following a 6 month lower limb strengthening program. It is speculated that following 6 months of strengthening exercise, subjects move about more rapidly and with greater stability than subjects in the control group, and that change in strength correlates (r>.8) directly with change in locomotor velocity and torques, and inversely with use of segmental momentum transfer during locomotor activities; and 3) to ascertain whether improvement in functional ability results in a change in disability. It is proposed that changes in functional abilities identified under Aim #2 will, in turn, result in improvements in disability during real life role activities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012561-04
Application #
2442291
Study Section
Geriatrics and Rehabilitation Medicine (GRM)
Project Start
1994-09-10
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
2000-06-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Scarborough, Donna Moxley; McGibbon, Chris A; Krebs, David E (2007) Chair rise strategies in older adults with functional limitations. J Rehabil Res Dev 44:33-42
Krebs, David E; Scarborough, Donna Moxley; McGibbon, Chris A (2007) Functional vs. strength training in disabled elderly outpatients. Am J Phys Med Rehabil 86:93-103
Amin, Shreyasee; Luepongsak, Niyom; McGibbon, Chris A et al. (2004) Knee adduction moment and development of chronic knee pain in elders. Arthritis Rheum 51:371-6
McGibbon, Chris A; Krebs, David E (2004) Discriminating age and disability effects in locomotion: neuromuscular adaptations in musculoskeletal pathology. J Appl Physiol 96:149-60
McGibbon, Chris A; Goldvasser, Dov; Krebs, David E et al. (2004) Instant of chair-rise lift-off can be predicted by foot-floor reaction forces. Hum Mov Sci 23:121-32
Dancewicz, Teresa M; Krebs, David E; McGibbon, Chris A (2003) Lower-limb extensor power and lifting characteristics in disabled elders. J Rehabil Res Dev 40:337-47
McGibbon, Chris A; Krebs, David E; Scarborough, Donna Moxley (2003) Rehabilitation effects on compensatory gait mechanics in people with arthritis and strength impairment. Arthritis Rheum 49:248-54
Luepongsak, N; Amin, S; Krebs, D E et al. (2002) The contribution of type of daily activity to loading across the hip and knee joints in the elderly. Osteoarthritis Cartilage 10:353-9
McGibbon, Chris A; Krebs, David E (2002) Compensatory gait mechanics in patients with unilateral knee arthritis. J Rheumatol 29:2410-9
McGibbon, C A; Puniello, M S; Krebs, D E (2001) Mechanical energy transfer during gait in relation to strength impairment and pathology in elderly women. Clin Biomech (Bristol, Avon) 16:324-33

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