Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG012954-05S1
Application #
2054808
Study Section
Special Emphasis Panel (ZRG1-NLS-1 (01))
Project Start
1991-09-01
Project End
1999-06-30
Budget Start
1995-09-30
Budget End
1996-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
Laifenfeld, Daphna; Patzek, Lucas J; McPhie, Donna L et al. (2007) Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis. J Neurosci 27:7141-53
Neve, Rachael L; McPhie, Donna L (2007) Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis. Biochim Biophys Acta 1772:430-7
Neve, Rachael L; McPhie, Donna L (2006) The cell cycle as a therapeutic target for Alzheimer's disease. Pharmacol Ther 111:99-113
Neve, Rachael L; Neve, Kim A; Nestler, Eric J et al. (2005) Use of herpes virus amplicon vectors to study brain disorders. Biotechniques 39:381-91
Herrup, Karl; Neve, Rachael; Ackerman, Susan L et al. (2004) Divide and die: cell cycle events as triggers of nerve cell death. J Neurosci 24:9232-9
Chen, Yuzhi; Liu, Wenyun; McPhie, Donna L et al. (2003) APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J Cell Biol 163:27-33
Neve, Rachael L (2003) A new wrestler in the battle between alpha- and beta-secretases for cleavage of APP. Trends Neurosci 26:461-3
McPhie, Donna L; Coopersmith, Robert; Hines-Peralta, Andrew et al. (2003) DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J Neurosci 23:6914-27
Carlezon Jr, William A; Neve, Rachael L (2003) Viral-mediated gene transfer to study the behavioral correlates of CREB function in the nucleus accumbens of rats. Methods Mol Med 79:331-50
Chen, Yuzhi; Liu, Wenyun; Naumovski, Louie et al. (2003) ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. J Neurochem 85:801-9

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