Abstract

The research outlined in this application is designed to (1) characterize the transition to menopause in a well-defined cohort of U.S. women, (2) analyze patterns of individual-level variation in reproductive aging, (3) relate these patterns of variation to previous history including information on reproduction, menstrual patterns, and health, and (4) link the hormonal changes of menopause to the underlying etiologic process of follicular depletion. The study population includes women enrolled in the Tremin Trust project: these women have been providing detailed prospective reports of menstrual and reproductive histories and other information for up to 30 years. For around 150 of these women, urine specimens will be collected during a six-month window for up to five years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG015141-05
Application #
6372159
Study Section
Social Sciences and Population Study Section (SSP)
Program Officer
Sherman, Sherry
Project Start
1997-06-01
Project End
2003-05-31
Budget Start
2001-06-15
Budget End
2003-05-31
Support Year
5
Fiscal Year
2001
Total Cost
$406,532
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
Organized Research Units
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802

  Publications

Ferrell, Rebecca J; Rodríguez, Germán; Holman, Darryl et al. (2012) Hypoestrogenic ""inactive phases"" at the start of the menstrual cycle: changes with age and reproductive stage, and relationship to follicular depletion. Fertil Steril 98:1246-53.e1-3
O'Connor, Kathleen A; Ferrell, Rebecca J; Brindle, Eleanor et al. (2009) Total and unopposed estrogen exposure across stages of the transition to menopause. Cancer Epidemiol Biomarkers Prev 18:828-36
O'Connor, Kathleen A; Ferrell, Rebecca; Brindle, Eleanor et al. (2009) Progesterone and ovulation across stages of the transition to menopause. Menopause 16:1178-87
Brindle, Eleanor; Miller, Rebecca C; Shofer, Jane B et al. (2006) Urinary beta-luteinizing hormone and beta-follicle stimulating hormone immunoenzymometric assays for population research. Clin Biochem 39:1071-9
O'Connor, K A; Brindle, E; Miller, R C et al. (2006) Ovulation detection methods for urinary hormones: precision, daily and intermittent sampling and a combined hierarchical method. Hum Reprod 21:1442-52
Ferrell, Rebecca J; O'Connor, Kathleen A; Rodriguez, German et al. (2005) Monitoring reproductive aging in a 5-year prospective study: aggregate and individual changes in steroid hormones and menstrual cycle lengths with age. Menopause 12:567-77
Miller, Rebecca C; Brindle, Eleanor; Holman, Darryl J et al. (2004) Comparison of specific gravity and creatinine for normalizing urinary reproductive hormone concentrations. Clin Chem 50:924-32
O'Connor, Kathleen A; Brindle, Eleanor; Shofer, Jane B et al. (2004) Statistical correction for non-parallelism in a urinary enzyme immunoassay. J Immunoassay Immunochem 25:259-78
O'Connor, Kathleen A; Brindle, Eleanor; Holman, Darryl J et al. (2003) Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin Chem 49:1139-48
O'Connor, K A; Holman, D J; Wood, J W (2001) Menstrual cycle variability and the perimenopause. Am J Hum Biol 13:465-78

Showing the most recent 10 out of 11 publications