Abstract

Abnormal plasma lipids are a major modifiable risk factor for cardiovascular (CV) disease in older persons. Polymorphic variation at numerous gene loci independently and via interactions with environmental factors affect plasma lipid levels. A cross-sectional study and preliminary data suggest that apolipoprotein E (APO E) genotype affects the HDL-C and HDL2-C increases that occur with exercise training. Thus, in healthy, sedentary, middle-aged and older subjects, the investigators will test their primary hypothesis: HDL-C and HDL2-C levels increase more with exercise training in APO E2/3 than in APO E3/4 genotype individuals. Preliminary data also indicate that lipoprotein lipase (LPL) Pvull genotype affects HDL-C and HDL2-C increases resulting from exercise training. Thus, they will test their secondary hypothesis: HDL-C and HDL2-C levels increase more with exercise training in LPL Pvull -/- than in LPL Pvull +/+ or +/- genotype individuals. Exploratory analyses will determine if variations at another LPL and 3 hepatic lipase (HL) gene loci affect the exercise training-induced HDL-C and HDL2-C increases and if, as with preliminary data, LPL and HL activities change differently with exercise training among genotype groups. After screening subjects for APO E genotype, they will be stabilized on an AHA Step I diet. Subjects then complete Baseline Testing, 6 months of exercise training and Final Testing. If VO2max, body composition, or intra-abdominal fat change differently among genotype groups with exercise training, they will be included in linear regression models to assess the independent effects of genetic and non-genetic variables on lipid changes with exercise training. Results consistent with the hypotheses will identify persons who obtain the greatest CV disease risk reductions, resulting in the optimal stratifying of exercise training to those benefiting the most. Conversely, identifying persons who will improve their lipoprotein lipids the least with exercise training would allow them to focus on interventions that might be more efficacious for them.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG015389-02
Application #
6016824
Study Section
Special Emphasis Panel (ZRG4-GRM (01))
Program Officer
Dutta, Chhanda
Project Start
1998-06-01
Project End
2003-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Maryland College Park
Department
Miscellaneous
Type
Schools of Public Health
DUNS #
City
College Park
State
MD
Country
United States
Zip Code
20742

  Publications

Barber, Jacob L; Kraus, William E; Church, Timothy S et al. (2018) Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions. Atherosclerosis 277:1-6
Sarzynski, Mark A; Burton, Jeffrey; Rankinen, Tuomo et al. (2015) The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions. Atherosclerosis 243:364-72
Bouchard, Claude; Blair, Steven N; Church, Timothy S et al. (2012) Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One 7:e37887
Prior, Steven J; Jenkins, Nathan T; Brandauer, Josef et al. (2012) Aerobic exercise training increases circulating insulin-like growth factor binding protein-1 concentration, but does not attenuate the reduction in circulating insulin-like growth factor binding protein-1 after a high-fat meal. Metabolism 61:310-6
Brinkley, Tina E; Halverstadt, Amy; Phares, Dana A et al. (2011) Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase. J Appl Physiol (1985) 111:1871-6
McKenzie, Jennifer A; Witkowski, Sarah; Ludlow, Andrew T et al. (2011) AKT1 G205T genotype influences obesity-related metabolic phenotypes and their responses to aerobic exercise training in older Caucasians. Exp Physiol 96:338-47
Jenkins, Nathan T; Hagberg, James M (2011) Aerobic training effects on glucose tolerance in prediabetic and normoglycemic humans. Med Sci Sports Exerc 43:2231-40
Jenkins, Nathan T; McKenzie, Jennifer A; Damcott, Coleen M et al. (2010) Endurance exercise training effects on body fatness, VO2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. J Appl Physiol (1985) 108:498-506
Brinkley, Tina E; Fenty-Stewart, Nicola M; Park, Joon-Young et al. (2009) Plasma nitrate/nitrite levels are unchanged after long-term aerobic exercise training in older adults. Nitric Oxide 21:234-8
Wilund, K R; Feeney, L A; Tomayko, E J et al. (2009) Effects of endurance exercise training on markers of cholesterol absorption and synthesis. Physiol Res 58:545-52

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