Based on brain Event-Related Potentials (ERP) obtained under tasks with designed memory demands, the aim is to improve understanding and foster early interventions by 1) developing non-invasive brain activity marker(s) for Alzheimer's disease (AD) early in its course, and 2) predicting with such marker(s) which patients with mild cognitive impairment (MCI) will go on to develop Alzheimer's disease. About half of MCI patients develop AD within a few years. The overall goal is to determine early enough which patients might benefit from interventions and to understand better the brain functions altered in these diseases. We record ERP's while participants perform two simple cognitive tasks. In each of these tasks, ERP components differ under conditions which demand different use of memory and processing resources. The two tasks are (1) a number-letter paradigm that involves comparisons of numbers or of letters within each trial of 4 sequential stimuli (working memory); and (2) a pattern paradigm which involves symmetry judgments of visual patterns, some of which are repeated over trials (implicit memory). The research entails comparison of tasks-related ERPs of MCI patients, AD patients early in the course of AD, and appropriately aged controls. Multivariate statistics are used to measure the ERP components and to develop functions that discriminate among the subject groups and predict AD among the MCI patients. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG018880-01A2
Application #
6610692
Study Section
Biobehavioral and Behavioral Processes 3 (BBBP)
Program Officer
Buckholtz, Neil
Project Start
2003-06-01
Project End
2008-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
1
Fiscal Year
2003
Total Cost
$275,625
Indirect Cost
Name
University of Rochester
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Chapman, Robert M; Gardner, Margaret N; Klorman, Rafael et al. (2018) Temporospatial components of brain ERPs as biomarkers for Alzheimer's disease. Alzheimers Dement (Amst) 10:604-614
Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark et al. (2016) ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do. Clin Neurophysiol 127:2423-35
Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark et al. (2015) Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage. Brain Res 1604:74-83
Chapman, Robert M; Porsteinsson, Anton P; Gardner, Margaret N et al. (2013) The impact of AD drug treatments on event-related potentials as markers of disease conversion. Curr Alzheimer Res 10:732-41
Chapman, Robert M; Porsteinsson, Anton P; Gardner, Margaret N et al. (2013) C145 as a short-latency electrophysiological index of cognitive compensation in Alzheimer's disease. J Alzheimers Dis 33:55-68
Chapman, Robert M; Mapstone, Mark; Gardner, Margaret N et al. (2011) Women have farther to fall: gender differences between normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women. J Int Neuropsychol Soc 17:654-62
Chapman, Robert M; Mapstone, Mark; McCrary, John W et al. (2011) Predicting conversion from mild cognitive impairment to Alzheimer's disease using neuropsychological tests and multivariate methods. J Clin Exp Neuropsychol 33:187-99
Chapman, Robert M; McCrary, John W; Gardner, Margaret N et al. (2011) Brain ERP components predict which individuals progress to Alzheimer's disease and which do not. Neurobiol Aging 32:1742-55
Chapman, Robert M; Mapstone, Mark; Porsteinsson, Anton P et al. (2010) Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses. J Clin Exp Neuropsychol 32:793-808
Chapman, Robert M; Mapstone, Mark; McCrary, John W et al. (2010) Cognitive Dimensions in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Elderly: Developing a Common Metric. Open Geriatr Med J 3:1-10

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