The elderly tend to be afflicted with impairments of several cognitive processes, including a decreased ability to pay attention, perform multiple tasks, and to time short intervals. Some models suggest a close interaction of timing and attention. The proposed studies hypothesize that attention and timing involve similar brain regions, in particular motor areas in the frontal lobe. In addition, it is predicted that dysfunction of the frontal motor areas is responsible for the age-related impairments in attention and timing. This dysfunction is due, in part, to the loss of cholinergic neurons of the nucleus basalis magnocellularis (NBM). The proposed studies do the following: 1) examine the effects of damage to motor cortex and NBM projections to motor cortex on attention and time estimation, 2) compare age-related changes of attention and timing in rats and humans, 3) examine the relationship between age-related loss of NBM neurons and impairments in attention and timing, and 4) investigate the effects of aging and brain damage on attention-related neuronal activity in motor cortex. The proposed behavioral studies with rats and humans involve similar versions of a simultaneous temporal processing (STP) task. In the STP task, subjects' learn to associate auditory and visual cues with short and long fixed time intervals, and are then tested on their ability to produce/estimate this time interval under different attentional demands. In a focused attention condition, only one cue is presented to subjects. In a divided attention condition, both cues are presented and must be attended to in order to respond correctly. The focused attention condition serves as a baseline measure of performance. The central empirical question concerns how aging and lesions (in rats) affect timing performance in divided attention conditions, relative to focused attention conditions. Model fits using scalar-expectance theory facilitate comparison between the human and rat behavioral data and potentially provide a functional interpretation of the effects of aging and lesions on focused and divided attention. Overall, the studies in this proposal will enhance our knowledge of the brain systems participating in attention and timing. Importantly, new information will be revealed that will elucidate the neural mechanisms responsible for age-related impairments in attention and timing. This new knowledge will provide directions for the development of treatments. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG020560-01A1
Application #
6580247
Study Section
Special Emphasis Panel (ZRG1-IFCN-4 (04))
Program Officer
Wagster, Molly V
Project Start
2003-02-15
Project End
2008-01-31
Budget Start
2003-02-15
Budget End
2004-01-31
Support Year
1
Fiscal Year
2003
Total Cost
$204,300
Indirect Cost
Name
Bowling Green State University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
617407325
City
Bowling Green
State
OH
Country
United States
Zip Code
43403
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McAuley, J D; Stewart, A L; Webber, E S et al. (2009) Wistar-Kyoto rats as an animal model of anxiety vulnerability: support for a hypervigilance hypothesis. Behav Brain Res 204:162-8
McAuley, J Devin; Miller, Nathaniel S (2007) Picking up the pace: effects of global temporal context on sensitivity to the tempo of auditory sequences. Percept Psychophys 69:709-18
McAuley, J Devin; Jones, Mari Riess; Holub, Shayla et al. (2006) The time of our lives: life span development of timing and event tracking. J Exp Psychol Gen 135:348-67
McAuley, J Devin; Miller, Jonathan P; Pang, Kevin C H (2006) Modeling the effects of the NMDA receptor antagonist MK-801 on timing in rats. Behav Neurosci 120:1163-8
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Miller, Nathaniel S; McAuley, J Devin (2005) Tempo sensitivity in isochronous tone sequences: the multiple-look model revisited. Percept Psychophys 67:1150-60
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