Manual dexterity is fundamental for maintaining independence in many basic and instrumental activities of daily living. Two important components of skill learning are the learning process itself (motor acquisition), and the ability to transfer what has been learned to new conditions and task variants (motor generalization). Many studies have documented declines in the ability of the elderly to learn new manual motor skills. Even though older adults exhibit reduced rates and magnitudes of skill acquisition in comparison to young adults, our recent work demonstrates that they show normal motor generalization. We propose that this newly documented age-related dissociation between acquisition and generalization is fundamentally important to clarifying the mechanisms and course of age-related motor declines. Moreover, this dissociation may provide new insights into acquisition and generalization processes and their neural underpinnings in the young adult. Recent behavioral and brain imaging investigations of skill acquisition suggest that motor learning consists not only of sensorimotor processes but also spatial cognitive processes, particularly during the early stages of learning. In the first aim of this project, we will use both behavioral and brain imaging techniques to investigate whether age-related declines in skill acquisition are associated with deficits in the early, spatial processing stages of learning. We will test this hypothesis using tasks that represent the two major classes of skill learning: sensorimotor adaptation and sequencing behaviors.
The second aim will examine whether motor generalization is associated with reduced involvement of these early learning spatial processes for both young and older adults. Thus, the overarching goal of this project is to describe and quantify the neural and behavioral mechanisms of age-related changes in skill acquisition and motor generalization. We predict that age-related declines in both sequence learning and sensorimotor adaptation are a result of deficits in the early, spatial cognitive aspects of skill acquisition. We predict that motor generalization, in comparison to original task learning, results in a reduced reliance on the spatial cognitive processes that are engaged during early skill acquisition, thus allowing for normal motor generalization in older adults. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG024106-02
Application #
7114883
Study Section
Cognition and Perception Study Section (CP)
Program Officer
Monjan, Andrew A
Project Start
2005-09-01
Project End
2009-07-31
Budget Start
2006-08-15
Budget End
2007-07-31
Support Year
2
Fiscal Year
2006
Total Cost
$360,419
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Szabo, Amanda N; Bangert, Ashley S; Reuter-Lorenz, Patricia A et al. (2013) Physical activity is related to timing performance in older adults. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 20:356-69
Seidler, Rachael D; Bo, Jin; Anguera, Joaquin A (2012) Neurocognitive contributions to motor skill learning: the role of working memory. J Mot Behav 44:445-53
Anguera, Joaquin A; Bernard, Jessica A; Jaeggi, Susanne M et al. (2012) The effects of working memory resource depletion and training on sensorimotor adaptation. Behav Brain Res 228:107-15
Bangert, Ashley S; Reuter-Lorenz, Patricia A; Seidler, Rachael D (2011) Dissecting the clock: understanding the mechanisms of timing across tasks and temporal intervals. Acta Psychol (Amst) 136:20-34
Anguera, Joaquin A; Reuter-Lorenz, Patricia A; Willingham, Daniel T et al. (2011) Failure to engage spatial working memory contributes to age-related declines in visuomotor learning. J Cogn Neurosci 23:11-25
Benson, Bryan L; Anguera, Joaquin A; Seidler, Rachael D (2011) A spatial explicit strategy reduces error but interferes with sensorimotor adaptation. J Neurophysiol 105:2843-51
Bo, J; Peltier, S J; Noll, D C et al. (2011) Symbolic representations in motor sequence learning. Neuroimage 54:417-26
Bo, J; Jennett, S; Seidler, R D (2011) Working memory capacity correlates with implicit serial reaction time task performance. Exp Brain Res 214:73-81
Bo, J; Peltier, S J; Noll, D C et al. (2011) Age differences in symbolic representations of motor sequence learning. Neurosci Lett 504:68-72
Langan, Jeanne; Seidler, Rachael D (2011) Age differences in spatial working memory contributions to visuomotor adaptation and transfer. Behav Brain Res 225:160-8

Showing the most recent 10 out of 28 publications