Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG026160-01
Application #
6932897
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (M1))
Program Officer
Carrington, Jill L
Project Start
2004-09-15
Project End
2009-06-30
Budget Start
2004-09-15
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$408,585
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Biochemistry
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Martin, Peter D; James, Zachary M; Thomas, David D (2018) Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. Biophys J 114:2573-2583
Her, Cheng; Thompson, Andrew R; Karim, Christine B et al. (2018) Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels. Sci Rep 8:10681
Guhathakurta, Piyali; Prochniewicz, Ewa; Roopnarine, Osha et al. (2017) A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure. Biophys J 113:91-100
Lewis, Andrew K; Dunleavy, Katie M; Senkow, Tiffany L et al. (2016) Oxidation increases the strength of the methionine-aromatic interaction. Nat Chem Biol 12:860-6
Gomez-Hurtado, Nieves; Boczek, Nicole J; Kryshtal, Dmytro O et al. (2016) Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol 9:
Her, Cheng; McCaffrey, Jesse E; Thomas, David D et al. (2016) Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin. Biophys J 111:2387-2394
Guhathakurta, Piyali; Prochniewicz, Ewa; Thomas, David D (2015) Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain. Proc Natl Acad Sci U S A 112:4660-5
Ablorh, Naa-Adjeley D; Thomas, David D (2015) Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy. Biophys Rev 7:63-76
Binder, Benjamin P; Cornea, Sinziana; Thompson, Andrew R et al. (2015) High-resolution helix orientation in actin-bound myosin determined with a bifunctional spin label. Proc Natl Acad Sci U S A 112:7972-7
Moen, Rebecca J; Klein, Jennifer C; Thomas, David D (2014) Electron paramagnetic resonance resolves effects of oxidative stress on muscle proteins. Exerc Sport Sci Rev 42:30-6

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