The long term objectives of this research are to identify the mechanisms of neuromechanical (NM) impairments underlying postural balance dysfunction in older people, and to establish a scientifically grounded therapeutic program for enhancing balance function and reducing the risk of falls. When human balance is challenged, the stepping reaction is a powerful means of stabilizing the body and preventing falling. Protective stepping is therefore a vital strategy for maintaining balance during activities of daily life. We propose that aging limitations in regional medio-lateral (M-L) hip abductor/adductor (AB/AD) NM responses compromise lateral balance stability by disrupting protective stepping. Consequently, many older people may be particularly vulnerable to lateral instability and injurious falls. Accordingly, our aims involve experimental, modeling, and interventional approaches to understanding these relationships.
Aim one is to a) identify the balance perturbation magnitude level at which older subjects transition to a riskier and more problematic crossover protective stepping pattern due to limitations in hip AB/AD NM control as determined by movement kinetics and kinematics;and to b) assess whether balance perturbation magnitude and associated stepping and hip AB/AD NM response measures discriminate between subjects with low fall risk and those with high fall risk.
Aim two is to develop and apply a computational model that predicts the balance limits of M-L stepping patterns in relation to regional hip AB/AD NM limitations.
Aim three is to assess feasibility factors (compliance, tolerance, benefits) necessary to advance a full-scale therapeutic intervention for preventing falls. We hypothesize that an intervention approach that combines induced step training and hip AB/AD muscle strengthening will demonstrate greater improvements in performance outcomes and fewer prospectively identified falls than either program performed alone.

Public Health Relevance

. The relevance of this research to public health lies in its focus on understanding the causes and interventions for minimizing the devastating economic, societal, and personal consequences of age-associated falls.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG029510-01A2
Application #
7460478
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Eldadah, Basil A
Project Start
2009-08-15
Project End
2011-07-31
Budget Start
2009-08-15
Budget End
2010-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$600,049
Indirect Cost
Name
University of Maryland Baltimore
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Addison, Odessa; Inacio, Mario; Bair, Woei-Nan et al. (2017) Role of Hip Abductor Muscle Composition and Torque in Protective Stepping for Lateral Balance Recovery in Older Adults. Arch Phys Med Rehabil 98:1223-1228
Fujimoto, Masahiro; Bair, Woei-Nan; Rogers, Mark W (2017) Single and multiple step balance recovery responses can be different at first step lift-off following lateral waist-pull perturbations in older adults. J Biomech 55:41-47
Singh, Harshvardhan; Sanders, Ozell; McCombe Waller, Sandy et al. (2017) Relationship Between Head-Turn Gait Speed and Lateral Balance Function in Community-Dwelling Older Adults. Arch Phys Med Rehabil 98:1955-1961
Bair, Woei-Nan; Prettyman, Michelle G; Beamer, Brock A et al. (2016) Kinematic and behavioral analyses of protective stepping strategies and risk for falls among community living older adults. Clin Biomech (Bristol, Avon) 36:74-82
Fujimoto, Masahiro; Bair, Woei-Nan; Rogers, Mark W (2015) Center of pressure control for balance maintenance during lateral waist-pull perturbations in older adults. J Biomech 48:963-8
Addison, Odessa; Young, Patricia; Inacio, Mario et al. (2014) Hip but not thigh intramuscular adipose tissue is associated with poor balance and increased temporal gait variability in older adults. Curr Aging Sci 7:137-43
Inacio, Mario; Ryan, Alice S; Bair, Woei-Nan et al. (2014) Gluteal muscle composition differentiates fallers from non-fallers in community dwelling older adults. BMC Geriatr 14:37
Young, Patricia M; Whitall, Jill; Bair, Woei-Nan et al. (2013) Leg preference associated with protective stepping responses in older adults. Clin Biomech (Bristol, Avon) 28:927-32
Yungher, Don A; Morgia, Judith; Bair, Woei-Nan et al. (2012) Short-term changes in protective stepping for lateral balance recovery in older adults. Clin Biomech (Bristol, Avon) 27:151-7