Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG029979-06
Application #
9316754
Study Section
Biochemistry and Biophysics of Membranes Study Section (BBM)
Program Officer
Wise, Bradley C
Project Start
2011-09-01
Project End
2017-06-30
Budget Start
2017-03-01
Budget End
2017-06-30
Support Year
6
Fiscal Year
2015
Total Cost
$51,123
Indirect Cost
$24,216
Name
Van Andel Research Institute
Department
Type
Research Institutes
DUNS #
129273160
City
Grand Rapids
State
MI
Country
United States
Zip Code
49503
Takeuchi, Hideyuki; Yu, Hongjun; Hao, Huilin et al. (2017) O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking. J Biol Chem 292:15964-15973
Tian, Ye; Zhang, Yugang; Wang, Tong et al. (2016) Lattice engineering through nanoparticle-DNA frameworks. Nat Mater 15:654-61
Liu, Wenyan; Tagawa, Miho; Xin, Huolin L et al. (2016) Diamond family of nanoparticle superlattices. Science 351:582-6
Yu, Hongjun; Takeuchi, Hideyuki; Takeuchi, Megumi et al. (2016) Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat Chem Biol 12:735-40
Yu, Hongjun; Takeuchi, Megumi; LeBarron, Jamie et al. (2015) Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nat Chem Biol 11:847-54
Tian, Ye; Wang, Tong; Liu, Wenyan et al. (2015) Prescribed nanoparticle cluster architectures and low-dimensional arrays built using octahedral DNA origami frames. Nat Nanotechnol 10:637-44
Sun, Jingchuan; Shi, Yi; Georgescu, Roxana E et al. (2015) The architecture of a eukaryotic replisome. Nat Struct Mol Biol 22:976-82
Li, Huilin; Wolfe, Michael S; Selkoe, Dennis J (2009) Toward structural elucidation of the gamma-secretase complex. Structure 17:326-34
Osenkowski, Pamela; Li, Hua; Ye, Wenjuan et al. (2009) Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol 385:642-52