Mobility problems affect 1/4 of all Americans aged 70 years or older. Primary care--based mobility testing has been advocated as an important clinical test for identifying those at risk for subsequent mobility decline and disability. Ideally, rehabilitation for those at risk should address the impairments that are most responsible for mobility decline. We define these as Rehabilitative Impairments and have identified 9 rehabilitative impairments as encompassing the most common foci of contemporary rehabilitation programs. In recognizing that many of these factors are interrelated, our previous work and experience suggests that rehabilitative impairments are encompassed within four distinct categories (Strength, Speed, Stability and Capacity), which we refer to as Rehabilitative Impairment Domains (RID). We hypothesize that the final common pathway between the most common medical conditions and mobility decline will be characterized by differing patterns of RID presentation. Surprisingly, given the high prevalence of mobility limitations and their clinical importance, there are no established mobility care guidelines concerning mobility risk factor screening and intervention as a means of preventing disability among older primary care patients. For older patients vulnerable to fatigue and frailty, optimal mobility rehabilitation should be directed toward those few RID and RID combinations most responsible for mobility decline. However, without better evidence determining which impairments and nonphysical factors to prioritize through rehabilitation, rehabilitative care will inevitably be more """"""""an art than a science"""""""" - dependent on the subjective views and experiences of individual practitioners. In contrast, with a clearer understanding of the risk factors to target, rehabilitative care can be a vital component of a successful primary-care based disability prevention strategy. We propose to conduct a prospective cohort study among 420 primary care patients, aged 65 years and older that manifest preclinical disability. Over 2 years of follow up, we plan to evaluate these 9 rehabilitative impairments identifying the distinct RID patterns most responsible for decline and disability. Preliminary work suggests that RID characteristic of Strength, Speed, Stability and Capacity may be most responsible. This investigation will address three specific aims: (1) At baseline, we will examine the RID represented by these 9 rehabilitative impairments and evaluate what patterns of RID are associated with current mobility limitation as measured by the Function component of the Late Life Function and Disability Instrument (LLFDI);(2) We will test which RID and RID combinations presenting at baseline predict future decline in mobility function as measured by the Function component of the LLFDI over two years;(3) We will test which RID and RID combinations present at baseline predict the progression of disability as measured by the Disability components of the LLFDI over two years. Filling this knowledge gap will allow for the development of primary care-based rehabilitative strategies to prevent disability.

Public Health Relevance

Difficulty with walking, climbing stairs and other basic mobility tasks affect almost 1/4 of adults over the age of 65 years and are predictive of such problems as falls, hospitalizations and even death. Our study will identify which physical factors, correctable through rehabilitation, are most responsible for worsening mobility among older primary care patients. The results will lead to studies evaluating the use of rehabilitation as a means of preventing disability among older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Neurological, Aging and Musculoskeletal Epidemiology (NAME)
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Joseph, Lyndon
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Spaulding Rehabilitation Hospital
United States
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Burkhart, Katelyn A; Bruno, Alexander G; Bouxsein, Mary L et al. (2018) Estimating apparent maximum muscle stress of trunk extensor muscles in older adults using subject-specific musculoskeletal models. J Orthop Res 36:498-505
Schmidt, Catherine T; Ward, Rachel E; Suri, Pradeep et al. (2018) Which Neuromuscular Attributes Are Associated With Changes in Mobility Among Community-Dwelling Older Adults With Symptomatic Lumbar Spinal Stenosis? Arch Phys Med Rehabil 99:2190-2197
Shea, Cristina A; Ward, Rachel E; Welch, Sarah A et al. (2018) Inability to Perform the Repeated Chair Stand Task Predicts Fall-Related Injury in Older Primary Care Patients. Am J Phys Med Rehabil 97:426-432
Schmidt, Catherine T; Ward, Rachel E; Suri, Pradeep et al. (2017) Health Characteristics, Neuromuscular Attributes, and Mobility Among Primary Care Patients With Symptomatic Lumbar Spinal Stenosis: A Secondary Analysis. J Geriatr Phys Ther 40:135-142
Romine, Perrin E; Kiely, Dan K; Holt, Nicole et al. (2017) Task-Specific Fatigue Among Older Primary Care Patients. J Aging Health 29:310-323
Schmidt, Catherine T; Ward, Rachel E; Suri, Pradeep et al. (2017) Association of Neuromuscular Attributes With Performance-Based Mobility Among Community-Dwelling Older Adults With Symptomatic Lumbar Spinal Stenosis. Arch Phys Med Rehabil 98:1400-1406
Beauchamp, Marla K; Jette, Alan M; Ni, Pengsheng et al. (2016) Leg and Trunk Impairments Predict Participation in Life Roles in Older Adults: Results From Boston RISE. J Gerontol A Biol Sci Med Sci 71:663-9
Makris, Una E; Paul, Tracy M; Holt, Nicole E et al. (2016) The Relationship Among Neuromuscular Impairments, Chronic Back Pain, and Mobility in Older Adults. PM R 8:738-47
Ward, Rachel E; Beauchamp, Marla K; Latham, Nancy K et al. (2016) Neuromuscular Impairments Contributing to Persistently Poor and Declining Lower-Extremity Mobility Among Older Adults: New Findings Informing Geriatric Rehabilitation. Arch Phys Med Rehabil 97:1316-22
Schepker, Caroline A; Leveille, Suzanne G; Pedersen, Mette M et al. (2016) Effect of Pain and Mild Cognitive Impairment on Mobility. J Am Geriatr Soc 64:138-43

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