Research has suggested that greater social engagement ? a term used to refer broadly to both quantitative and qualitative aspects of social interaction ? is associated with significantly lower risks for cognitive decline and dementia in older adults. The question of whether and how social engagement may begin to affect adult cognition earlier in the life course remains unanswered, as do questions regarding which aspects of social engagement may be most influential, and whether these effects reflect cumulative histories of social engagement or only more current levels of engagement. Drawing on rich longitudinal data about social engagement (from childhood relationships with parents through current adult relationships) from the Mid-Life in the US (MIDUS) I and II studies, as well as innovative new MIDUS biological and cognitive data, this application proposes a series of analyses designed to significantly advance our understanding of how histories of social engagement may impact on adult cognitive functioning, expanding on prior research to answer the following questions: 1) Considering both quantitative/structural and qualitative aspects of social engagement, which features are most consequential to adult cognition?;2) Are social engagement influences cumulative (i.e., does historical information extending potentially as far back as childhood relationships with parents help to account for observed differences in adult cognitive functioning)?;3) Are histories of social engagement related to adult cognition in younger and middle-aged (as well as older) adults and, if so, are the relationships similar or different at younger versus older ages?;4) Are there sex or socio-economic (SES) differences in the patterning of the relationship between social engagement and cognition?;5) To what extent is the relationship explained by frequently hypothesized mediators such as health behaviors and/or health conditions?;and 6) to what extent do major biological regulatory systems appear to mediate the relationship between social engagement and adult cognition (i.e., how does social engagement ?get under the skin?)? Answers to these questions will serve to significantly extend our understanding of whether and how social engagement may influence cognition from younger through older adulthood, and how these relationships may be moderated by age, sex or SES. Only through greater understanding of the intricacies of these relationships can we hope to be successful in any future efforts to reduce risks of cognitive decline and/or impairment for those made more vulnerable as a result of less advantaged social histories.

Public Health Relevance

Research has suggested that greater social engagement (i.e., the quantity and quality of our social relationships) is associated with significantly lower risks for cognitive decline and dementia in older adults. The proposed research will examine whether social engagement starts to benefit cognitive function at younger ages since evidence of effects earlier in adulthood would indicate that efforts directed at improving cognition by enhancing social engagement should start well before older age. This project will also investigate whether sex or socio-economic status influence the relationship between social engagement and cognition as enhanced understanding of relationships between social engagement and adult cognition for men and women and for those of lower and higher socio-economic status will be essential to the success of any future efforts to design interventions to reduce risks of cognitive decline for those made more vulnerable to it as a result of less advantaged social histories.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG032271-02
Application #
7915451
Study Section
Special Emphasis Panel (ZRG1-RPHB-K (02))
Program Officer
King, Jonathan W
Project Start
2009-08-15
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2012-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$484,670
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Crandall, C J; Karlamangla, A S; Merkin, S S et al. (2015) Adult bone strength of children from single-parent families: the Midlife in the United States Study. Osteoporos Int 26:931-42
Miller-Martinez, D; Seeman, T; Karlamangla, A S et al. (2014) Marital histories, marital support, and bone density: findings from the Midlife in the United States Study. Osteoporos Int 25:1327-35
Brooks, Kathryn P; Gruenewald, Tara; Karlamangla, Arun et al. (2014) Social relationships and allostatic load in the MIDUS study. Health Psychol 33:1373-81
Seeman, Melvin; Stein Merkin, Sharon; Karlamangla, Arun et al. (2014) Social status and biological dysregulation: the ""status syndrome"" and allostatic load. Soc Sci Med 118:143-51
Karlamangla, Arun S; Miller-Martinez, Dana; Lachman, Margie E et al. (2014) Biological correlates of adult cognition: midlife in the United States (MIDUS). Neurobiol Aging 35:387-94
Mori, Takahiro; Karlamangla, Arun S; Merkin, Sharon Stein et al. (2014) Multisystem dysregulation and bone strength: findings from the study of midlife in the United States. J Clin Endocrinol Metab 99:1843-51
Human, Lauren J; Biesanz, Jeremy C; Miller, Gregory E et al. (2013) Is change bad? Personality change is associated with poorer psychological health and greater metabolic syndrome in midlife. J Pers 81:249-60
Tun, Patricia A; Miller-Martinez, Dana; Lachman, Margie E et al. (2013) Social strain and executive function across the lifespan: the dark (and light) sides of social engagement. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 20:320-38
Karlamangla, Arun S; Mori, Takahiro; Merkin, Sharon S et al. (2013) Childhood socioeconomic status and adult femoral neck bone strength: findings from the Midlife in the United States Study. Bone 56:320-6
Crandall, Carolyn J; Merkin, Sharon Stein; Seeman, Teresa E et al. (2012) Socioeconomic status over the life-course and adult bone mineral density: the Midlife in the U.S. Study. Bone 51:107-13

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