Compared to non-Hispanic Whites (Whites), racial/ethnic minorities suffer from higher prevalence of Alzheimer?s disease (AD) and some associated vascular conditions, exhibit lower medication adherence, and incur higher healthcare costs. A critical barrier for resolving racial/ethnic disparities among AD patients is the lack of effective strategies to improve medication utilization among this population. Our Parent R01 examines the effects of medication therapy management (MTM) programs in the Medicare prescription drug benefit (Part D) on racial/ethnic disparities, but our original plan did not include AD-specific analysis mainly because of small sample size. With newly granted access to data for 100% Medicare beneficiaries, we now propose to examine the effects of MTM on medication utilization and health services utilization/costs among AD patients. The Centers for Medicare & Medicaid Services (CMS) established MTM in 2006 to improve pharmacotherapy outcomes, but because of program design issues, CMS decided to modify MTM and launched a demonstration of the Enhanced MTM Model in 2017. While the existing MTM has been shown to lead to higher medication adherence among patients with vascular conditions, based on an interim report from 10/2019, Enhanced MTM failed to exert a positive impact on utilization of medications or health services. Our study will thus provide timely information when CMS ponders MTM policy options after completing the Enhanced MTM demonstration in 2022. Our long-term goal is to improve the health status of older adults among diverse populations by reducing racial/ethnic disparities in medication utilization and health outcomes. We will analyze 100% Medicare Parts A/B/D data (2016-2017) linked to Area Health Resources Files. For medication utilization, we will measure initiation/discontinuation/persistence of antidementia medication and will apply utilization measures of medications, including those for vascular conditions, in Part D Star Ratings, a federal health-plan-quality evaluation system. Our expected outcomes include new information on: (1) effects of MTM on study outcomes among AD patients; (2) effects of MTM on racial/ethnic disparities in study outcomes among AD patients; and (3) measures of MTM utilization that exhibit disparity patterns among AD patients.
Aim 1 : Test the hypothesis that MTM services have improved quality of medication utilization and reduced health services utilization/costs among AD patients.
Aim 2 : Test the hypothesis that MTM has reduced racial/ethnic disparities in medication utilization and health services utilization/costs among AD patients.
Aim 3 : Test the hypothesis that racial/ethnic minorities received fewer/delayed MTM services than Whites among AD patients. Impact: Our results will provide empirical evidence to guide CMS policy-making for MTM, improve AD management, and assist the NIA/NIH in its strategic goals of ?develop(ing) strategies to improve the health status of older adults in diverse populations.? Because the existing MTM has been shown to improve medication utilization among individuals with vascular conditions, this study is highly likely to produce meaningful results.

Public Health Relevance

Our long-term goal is to improve the health status of older adults in diverse populations by improving medication utilization and reducing racial/ethnic disparities in medication utilization and health outcomes. Our results will provide much-needed empirical evidence to guide policy- making by the Centers for Medicare & Medicaid Services, improve the management of Alzheimer?s disease, and assist the National Institute on Aging/National Institutes of Health in its strategic goals of informing ?policy decisions,? and ?understand(ing) health disparities and develop(ing) strategies to improve the health status of older adults in diverse populations.?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG040146-05S1
Application #
10121850
Study Section
Health Disparities and Equity Promotion Study Section (HDEP)
Program Officer
Phillips, John
Project Start
2011-09-01
Project End
2022-12-31
Budget Start
2020-08-01
Budget End
2021-12-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38103
Jamison, JoEllen Jarrett; Wang, Junling; Surbhi, Satya et al. (2016) Impact of Medicare Part D on Racial and Ethnic Minorities. Divers Equal Health Care 13:326-333
Wang, Junling; Hong, Song Hee (2015) Contingent valuation and pharmacists' acceptable levels of compensation for medication therapy management services. Res Social Adm Pharm 11:e121-32
Wang, Junling; Qiao, Yanru; Shih, Ya-Chen Tina et al. (2015) Potential Health Implications of Medication Therapy Management Eligibility Criteria in the Patient Protection and Affordable Care Act Across Racial and Ethnic Groups. J Manag Care Spec Pharm 21:993-1003
Wang, Junling; Qiao, Yanru; Tina Shih, Ya-Chen et al. (2014) Potential health implications of racial and ethnic disparities in meeting MTM eligibility criteria. Res Social Adm Pharm 10:106-125
Wang, Junling; Munshi, Kiraat D; Hong, Song Hee (2014) Racial and ethnic disparities in influenza vaccinations among community pharmacy patients and non-community pharmacy respondents. Res Social Adm Pharm 10:126-40
Wang, Junling; Surbhi, Satya; Kuhle, Julie W (2014) Receipt of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers among Medicare Beneficiaries with Diabetes and Hypertension. J Pharm Health Serv Res 5:67-74
Wang, Junling; Surbhi, Satya; Zhang, Zhiping et al. (2014) Historical trend of racial and ethnic disparities in meeting Medicare medication therapy management eligibility in non-Medicare population. Res Social Adm Pharm 10:904-917
Wang, Junling; Qiao, Yanru; Tina Shih, Ya-Chen et al. (2014) Potential effects of racial and ethnic disparities in meeting Medicare medication therapy management eligibility criteria. J Pharm Health Serv Res 5:109-118
Munshi, Kiraat D; Shih, Ya-Chen T; Brown, Lawrence M et al. (2013) Disparity implications of the Medicare medication therapy management eligibility criteria: a literature review. Expert Rev Pharmacoecon Outcomes Res 13:201-16
Wang, Junling; Ford, Lindsay J; Wingate, La'Marcus et al. (2013) Effect of pharmacist intervention on herpes zoster vaccination in community pharmacies. J Am Pharm Assoc (2003) 53:46-53

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