Pre mortem tests of Alzheimer's disease (AD) pathology are increasingly popular in research on cognitive aging and AD. Due to concerns that information from such tests may be misunderstood, psychologically harmful, and of unclear clinical significance, results of pre mortem tests of AD pathology have typically been withheld from research participants. However, as the reliability and potential clinical significance of test like brain amyloid imaging have become clear, there is a pressing need to revisit the practice of unilaterally withholding such information from research participants and identify responsible approaches to communicating individual results. Amyloid imaging results may be particularly relevant to mild cognitive impairment (MCI), a population for whom a growing body of evidence suggests that such testing may provide valuable prognostic and planning information, despite the unavailability of interventions to alter one's clinical course. Our preliminary work suggests that research participants with MCI and their family members are receptive to and capable of understanding information about the purpose, results, and implications of amyloid imaging when presented using a standardized approach developed by our interdisciplinary team. Building on this work, the proposed study, led by an early stage investigator in response to PA-11-180, will follow a well characterized sample of at least 40 MCI care dyads (patient + family member) who are, and a matched comparison group of dyads who are not, presented with the option of receiving the patient's amyloid imaging research results.
Aim 1 will test hypotheses that examine how receiving amyloid imaging research results will impact understanding of, and perceived self-efficacy for coping with, MCI among both patients and care partners.
Aim 2 will use a series of qualitative interviews and content analysis to identify the information and support needs of MCI care dyads who are offered amyloid imaging research results. A third, exploratory aim will document, within the subgroup of MCI care dyads who receive amyloid imaging research results, the frequency, nature, and range of psychological and behavioral responses to receiving such results. In addition to having implications for research conduct, our findings may also inform clinical practice as clinicians begin to incorporate amyloid imaging into clinical evaluation and respond to patient requests for such imaging.

Public Health Relevance

This project will examine how patients at heightened risk for dementia and their immediate family members undertake decisions to pursue, and react to results of, amyloid imaging, a technology which allows for the premortem identification of Alzheimer's pathology in the brain. Because persons who are amyloid positive represent key targets of future trials of anti-amyloid drug therapies and other secondary prevention strategies for dementia, it is of high public health significance to understand the acceptability of, and reactions to, amyloid imaging technology among such individuals.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Special Emphasis Panel (SEIR)
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Silverberg, Nina B
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University of Pittsburgh
Other Domestic Higher Education
United States
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Grill, Joshua D; Apostolova, Liana G; Bullain, Szofia et al. (2017) Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther 9:35
Patel, Rina; Eltgroth, Matthew; Souza, Richard et al. (2016) Loaded versus unloaded magnetic resonance imaging (MRI) of the knee: Effect on meniscus extrusion in healthy volunteers and patients with osteoarthritis. Eur J Radiol Open 3:100-7
Lingler, Jennifer H; Butters, Meryl A; Gentry, Amanda L et al. (2016) Development of a Standardized Approach to Disclosing Amyloid Imaging Research Results in Mild Cognitive Impairment. J Alzheimers Dis 52:17-24