Neurocognitive disorders (e.g., Alzheimer's disease) are major public health problems that may disproportionately affect Latinos compared to other Americans. Extant dementia literature from outstanding neuroepidemiologic work indicates that some Latino ancestry groups may have a four-fold increased risk of dementing disorders (e.g., Alzheimer's disease) compared to other Latino groups. The reasons for these striking differences in dementia estimates have not been addressed; represent a major gap in the health scientific literature; and form a major barrier to progress in better understanding dementias among diverse Latino populations. Furthermore, less is known about midlife factors associated with early and pathological neurocognitive deficits and disordrs, regardless of ethnicity/race. Insights from middle-aged and older Latino populations will open new opportunities for mitigating further neurocognitive disorder and related disabilities. Logistically and economically, sampling sufficient numbers of major Latino groups (e.g., Mexicans, Puerto Ricans, Cubans, Dominicans) for well-powered neuroepidemiologic work is prohibitive and forms additional barriers to progress in the field. As an invited Ancillary Study of the Hispanic Community Health Study/Study of Latinos (SOL; n=16,415 at baseline), this proposed project designated as the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) would efficiently fill major gaps in the neuroepidemiology Mild Cognitive Impairment/Mild Neurocognitive Disorders (MCI/mNCD). SOL-INCA would examine associations between shared genetic and cardiovascular disease risk factors for neurocognitive deficits and disorders (i.e., MCI/mNCD) among SOL's middle-aged and older Latino subsample (n=9,652 at baseline). Additionally, SOL-INCA would begin to unveil the sociocultural risks and protective factors that may contribute the striking differences in dementia previously found between Latino ancestry groups. SOL-INCA would be integrated into Visit 2 to collect a second time-point of neurocognitive data from returning SOL middle-aged and older Latinos participants (ages 50-80 years old; 2015-2020). We believe that the SOL-INCA approach would enable us to discover behaviorally, culturally appropriate, and biologically plausible targets and means for mitigating early neurocognitive disorders. Our long-term is to translate our findings into actionable means for preventing or delaying milder forms of neurocognitive disorders from evolving into more severe disordered states, especially in Latinos who may be at increased risk for these disorders.

Public Health Relevance

The proposed Study of Latinos-Investigation of Neurocognitive Aging would examine neurocognitive disorders (e.g., Mild Cognitive Disorders, Alzheimer's disease), which are major public health problems that may disproportionately affect Latinos compared to other Americans. The proposed study directly addresses key aspects of the US National Plan to Address Alzheimer's Disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG048642-02
Application #
9134025
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Anderson, Dallas
Project Start
2015-09-01
Project End
2020-04-30
Budget Start
2016-05-15
Budget End
2017-04-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Michigan State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
González, Hector M; Tarraf, Wassim; Harrison, Kimystian et al. (2018) Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results. Alzheimers Dement 14:579-589
Estrella, Mayra L; Rosenberg, Natalya I; Durazo-Arvizu, Ramon A et al. (2018) The association of employment status with ideal cardiovascular health factors and behaviors among Hispanic/Latino adults: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). PLoS One 13:e0207652
Camacho, Alvaro; Tarraf, Wassim; Jimenez, Daniel E et al. (2018) Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results. Am J Geriatr Psychiatry 26:238-249
González, Hector M; Tarraf, Wassim; Vásquez, Priscilla et al. (2018) Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results. Diabetes Care 41:1501-1509
Tarraf, Wassim; Criqui, Michael H; Allison, Matthew A et al. (2018) Ankle brachial index and cognitive function among Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos. Atherosclerosis 271:61-69
Vásquez, Elizabeth; Strizich, Garrett; Isasi, Carmen R et al. (2017) Is there a relationship between accelerometer-assessed physical activity and sedentary behavior and cognitive function in US Hispanic/Latino adults? The Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Prev Med 103:43-48
Tarraf, Wassim; Rodríguez, Carlos J; Daviglus, Martha L et al. (2017) Blood Pressure and Hispanic/Latino Cognitive Function: Hispanic Community Health Study/Study of Latinos Results. J Alzheimers Dis 59:31-42
Lamar, Melissa; Wu, Donghong; Durazo-Arvizu, Ramon A et al. (2017) Cognitive Associates of Current and More Intensive Control of Hypertension: Findings From the Hispanic Community Health Study/Study of Latinos. Am J Hypertens 30:624-631
Strizich, Garrett; Kaplan, Robert C; González, Hector M et al. (2016) Glycemic control, cognitive function, and family support among middle-aged and older Hispanics with diabetes: The Hispanic Community Health Study/Study of Latinos. Diabetes Res Clin Pract 117:64-73
Ramos, Alberto R; Tarraf, Wassim; Daviglus, Martha et al. (2016) Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos. Sleep 39:1843-1851

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