A number of surveys of health and cognition in older adults conducted outside of the US are modeled after the US Health and Retirement Study (HRS). Each of these international sister studies (ISS) uses different methods to assess cognitive functioning. These differences, combined with differences in the environment, languages, demographic and health characteristics of the participants make it difficult to draw clear conclusions regarding similarities and differences in the level of cognitive impairment cross-nationally. The ability to compare rates of dementia and more broadly cognitive impairment internationally is of interest to policy makers and public health leaders. Health ministries require reliable information regarding the comparative burden and potential impact of cognitive impairment among their older citizens to evaluate previous public responses and plans for future responses to demographic shifts. Our team is a productive and multidisciplinary group representing expertise in cognitive aging, psychometrics, neuropsychology, medicine, gerontology, and epidemiology. We have a long track record of collaboration in these areas, and extensive applied experience with the HRS international sister studies, including psychometric linking studies with direct relevance to the current application. Members of our team also include experts at the forefront of efforts to standardize and modernize health and cognitive assessments using state-of-the-art psychometric and computing approaches. Our application will: 1) harmonize and co-calibrate the cognitive assessments in the HRS family of studies, 2) identify limits of the validity of the measures, 3) and make concrete recommendations for future work and instrument development. We will accomplish these goals my making use of HRS and ISS, as well as other existing studies that include brief mental status assessments, neuropsychological tests, and relevant clinical outcomes for cognitive aging and dementia (neuroimaging, neuropathology, and longitudinal course).

Public Health Relevance

This application will address the conceptual and statistical equivalence of cognitive assessments between the HRS and international sister studies, and describe the extent to which comparisons are valid, and make recommendations to advance cognitive assessment in large scale research projects going forward. Without careful consideration of the conceptual and statistical equivalence of the different assessments, the data derived from these studies are not comparable. Effective public health planning and informative research requires harmonized cognitive assessment data from cross-national studies.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Special Emphasis Panel (ZAG1-ZIJ-4 (M1))
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Haaga, John G
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Brown University
Schools of Medicine
United States
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Mayeda, Elizabeth Rose; Filshtein, Teresa J; Tripodis, Yorghos et al. (2018) Does selective survival before study enrolment attenuate estimated effects of education on rate of cognitive decline in older adults? A simulation approach for quantifying survival bias in life course epidemiology. Int J Epidemiol 47:1507-1517
Mungas, Dan; Gavett, Brandon; Fletcher, Evan et al. (2018) Education amplifies brain atrophy effect on cognitive decline: implications for cognitive reserve. Neurobiol Aging 68:142-150
Hohman, Timothy J; Tommet, Doug; Marks, Shawn et al. (2017) Evaluating Alzheimer's disease biomarkers as mediators of age-related cognitive decline. Neurobiol Aging 58:120-128