The goal of this application is to identify patterns of perceived stress, active coping style,health status and genes that contribute to longevity observed within African American families.We will examine these factors using vertical and horizontal approaches by studying similaritiesbetween siblings and parent-child pairs. To this end, we have the following questions: 1) Do familial effects (genes and shared environments) create similarity in the patterns ofperceived tress and coping within and across generations? 2) Does stress account for differences in patterns of longevity between families? 3) Do psychosocial factors like stress, coping, and discrimination account for differences inpatterns of health status and longevity between families? 4) What role do genes play in patterns of stress and longevity? 5) Are there gene-environment interactions between genes associated with stress andlongevity and environmental factors such as family financial adversity and discrimination?To address these research questions, we have planned five specific aims:1) Collect data from 750 older African Americans on perceptions of stress, discrimination,coping style, health, personality and genetics from multi-generation families (parent-child andsiblings).2) Examine similarities and differences in stress and coping, and health status among siblingpairs and across generations within families.3) Compare the health status of siblings concordant for higher stress and poorer coping tothose with lower stress and better coping.4) Examine genes associated with stress and longevity in comparisons of long lived familiesand short lived families and among sibling pairs.5) Are there gene-environment interactions between genes associated with stress andlongevity and environmental factors such as family financial adversity and discrimination?This project is novel and innovative in that it will employ a multi method approach tounderstand longevity. It will use a quantitative genetic approach, a molecular geneticapproach, and a multi generation approach. To our knowledge, this is the first time all of thesemethods have been employed on one sample.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG054363-02
Application #
9393666
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (A1))
Program Officer
Nielsen, Lisbeth
Project Start
2016-09-30
Project End
2021-04-30
Budget Start
2017-02-01
Budget End
2017-04-30
Support Year
2
Fiscal Year
2016
Total Cost
$659,689
Indirect Cost
$42,562
Name
Wayne State University
Department
Type
Other Domestic Higher Education
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Thorpe Jr, Roland J; Whitfield, Keith E (2018) Psychosocial Influences of African Americans Men's Health. J Gerontol B Psychol Sci Soc Sci 73:185-187
Whitfield, Keith E; Thorpe Jr, Roland J (2017) Perspective: Longevity, Stress, Genes and African Americans. Ethn Dis 27:1-2
Thorpe Jr, Roland J; Whitfield, Keith E (2017) Advancing Minority Aging Research. Res Aging 39:471-475