ADRD-Focused Administrative Supplement to NIA Grant R01AG055481 PROJECT SUMMARY This is an application for an administrative supplement to NIA Grant R01AG055481 ? ?Educational Attainment, Geography, and U.S. Adult Mortality Risk? (PI: Jennifer Karas Montez) in response to PA-18-591 and, specifically, NOT-AG-18-008: Administrative supplements to expand existing NIH awards to include a focus on Alzheimer's Disease (AD) and its related dementias (ADRD). The primary objective of NIA Grant R01AG055481 is to determine how and why the education-mortality association varies across U.S. states and over time. The proposed supplement will complement the objective of the parent grant, but expand it to focus on ADRD in addition to mortality. Using longitudinal and geographically linked data from the nationally representative HRS, the proposed project will determine the degree of geographic variation in the association between education and prevalence of dementia and cognitive impairment with no dementia (CIND), how these associations change over a twelve-year period from 2000 to 2012, and whether state-level education policy explains regional variation in dementia and CIND prevalence and trends.
Clarifying the places and populations for which dementia has been declining is important for crafting policies and efforts directed at reducing the burden of dementia in the population. Findings from this project will provide important insights into the mechanisms underlying recently observed declines in dementia prevalence and can be used to formulate a multi-level approach to further reduce the prevalence of dementia in the population that considers both individual-level factors and the broader macro-social contexts in which dementia risk develops.
|Sheehan, Connor; Montez, Jennifer Karas; Sasson, Isaac (2018) Does the Functional Form of the Association Between Education and Mortality Differ by U.S. Region? Biodemography Soc Biol 64:63-81|
|Zajacova, Anna; Montez, Jennifer Karas (2018) Explaining the increasing disability prevalence among mid-life US adults, 2002 to 2016. Soc Sci Med 211:1-8|