Stroke is a major public health problem in the United States. It is the fifth leading cause of death and a leading cause of serious disability in adults. There are an estimated 800,000 strokes in the United States each year, with an estimated 7 million stroke survivors. Twenty percent of stroke survivors require institutional care after 3 months and 15%-30% are permanently disabled. Recurrent events, which occur in 185,000 stroke survivors in the United States each year, are associated with higher mortality rates, greater levels of disability, and increased costs as compared with first strokes. Stroke in adults is strongly age dependent, and the rate of adverse outcomes and complications associated with stroke increases with advanced age. Because the United States population is aging, the population at risk for stroke and recurrent events will increase over the coming decades. The high prevalence of stroke and its associated deficits impose a large burden on patients, their families, and the healthcare system. Optimizing post-acute care and secondary prevention efforts for stroke survivors represents an important target to reduce the burden of recurrent stroke, particularly among the elderly. Racial/ethnic and regional disparities have been identified for stroke incidence, prevalence, and mortality, but relatively little research has focused on potential disparities in the patterns of recurrent stroke events. The Disparities in Patterns of Recurrent Stroke in the Elderly study will use Medicare administrative data to achieve the following specific aims: 1) to assess temporal patterns in national recurrent stroke rates among elderly Medicare beneficiaries hospitalized with ischemic stroke and describe disparities by sociodemographic and comorbid/clinical characteristics; and 2) to determine county-level rates of recurrent stroke, the persistence of geographic patterns over time, and county-level factors that may be contributing to disparities. Clinical practice, public policy, and reimbursement decisions are increasingly informed by data obtained from administrative datasets. The Disparities in Patterns of Recurrent Stroke in the Elderly study will be the largest contemporary investigation of recurrent stroke rates and patterns in the United States. Results from this project will identify geographic areas and subgroups that have distinctive health profiles that put them at high risk for recurrent stroke. Such information will inform care providers, insurers, public health agencies, and policy makers about communities that may derive the greatest benefit from targeted programs and community-based interventions.

Public Health Relevance

Results from the study will provide clinicians, investigators, and policymakers with national data on rates, trends, and patterns of recurrent stroke hospitalizations among the elderly, including variation among patient subgroups and geographic regions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
Project #
Application #
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Public Health & Prev Medicine
Schools of Medicine
New Haven
United States
Zip Code