Alzheimer?s Disease Risk and Ethnic Factors: The Case of Arab Americans Alzheimer?s disease (AD) afflicts 11% of the U.S. population aged 65 and over, and half of these cases go undiagnosed. The incidence of mild cognitive impairment (MCI) and AD is higher among many racial/ ethnic minorities, but rates among Arab Americans, who possess more cardiovascular risk factors than whites, are unknown. The first of its kind, this study will collect regionally representative data from Arab Americans (N=600) aged 65 and over living in the metro-Detroit area, home to the largest and most visible Arab American community in the U.S. Additionally, we will leverage an existing sample of black and white older adults from the Survey of Social Relations (SRS) to compare and contrast prevalence of AD and the role of structural factors among Arab Americans to other populations in the same geographic area. The planned project will form the basis of a future prospective study to advance understanding of racial/ethnic health disparities in AD incidence.
The specific aims are to: 1) Characterize cognition and AD risk among Arab Americans in metro-Detroit; 2) Determine the contribution of immigrant factors to cognition and AD risk among older Arab Americans; 3) Identify aspects of social networks that have greatest effects on cognition and AD risk. This project will produce currently unavailable normative data that will assist practitioners in the assessment of AD in English and Arabic speaking Arab American elders. With a focus on AD disparities, and socio-behavioral factors, these data will provide opportunities to compare to regional and national data on other racial/ethnic minorities in the quest to quantify health disparities and identify mechanisms that cause and sustain them. In addition to delineating health disparities, studying Arab Americans can refine our understanding of immigrant health in the U.S. Further, the study of social networks among diverse racial/ethnic groups will reveal how and why social ties form and function as a protective factor (direct and buffering) on cognitive health. Understanding the role of structural and cultural factors will refine theory about AD disparities and provide key information to better develop intervention strategies for effective management of this growing and high-cost disease.

Public Health Relevance

Establishing prevalence rates of AD among Arab Americans, and comparing those rates to representative data of other racial/ethnic groups provides an innovative, cost effective opportunity to more fully delineate health disparities. This project will produce currently-unavailable normative data that will assist practitioners in the assessment of AD in Arab American elders. Understanding the role of structural and cultural factors will refine theory about AD disparities and provide key information to better develop intervention strategies for effective management of this growing and high-cost disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG057510-03
Application #
9973037
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
King, Jonathan W
Project Start
2018-09-15
Project End
2023-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
3
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biostatistics & Other Math Sci
Type
Organized Research Units
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109