We propose to acquire new neuroimaging measures concurrent with muscle measures in 40 adults participating in the Pittsburgh Clinical Center R01AG059416, ?Study of Muscle and Mobility in Aging (SOMMA). The goal of SOMMA is to study muscle aging as it relates to disability. The goal of the proposed expanded SOMMA-BRAIN is to identify, for the first time, novel modifiable shared brain-muscle energy characteristics best predicting resilience to fatigue and loss of mobility. By promoting an integrated study of central and peripheral causes of fatigue, this project will provide novel targets for prevention and treatment of fatigue. Additionally, this project would discover modifiable processes in muscle that may influence processes in the brain to, in turn, influence cognitive performance. The data would support a new grant application to NIA to expand the aims of SOMMA, as well as the number of participants and widen the eligibility criteria.

Public Health Relevance

Mobility disability, the inability to walk 400 meters, is common in the elderly and causes loss of independence and poor quality of life. The Study of Muscle, Mobility, and Aging will obtain muscle tissue from biopsies and advanced imaging of muscle to find properties that contribute to mobility disability that may give clues to about ways to prevent it.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG059416-03S1
Application #
10065711
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Joseph, Lyndon
Project Start
2018-06-15
Project End
2023-05-31
Budget Start
2020-09-15
Budget End
2021-05-31
Support Year
3
Fiscal Year
2020
Total Cost
Indirect Cost
Name
California Pacific Medical Center Research Institute
Department
Type
DUNS #
071882724
City
San Francisco
State
CA
Country
United States
Zip Code
94107