The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.

Public Health Relevance

The current proposal investigates markers of artery stiffness and resistance in the brains of older adults who may be at risk for Alzheimer's disease. Findings will have direct relevance for our understanding of Alzheimer's disease and the development of methods for assessing Alzheimer's risk and response to treatment during an early stage when interventions may be most helpful.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG060049-02
Application #
10027264
Study Section
Clinical Neuroscience and Neurodegeneration Study Section (CNN)
Program Officer
Mackiewicz, Miroslaw
Project Start
2019-08-01
Project End
2024-04-30
Budget Start
2020-01-15
Budget End
2020-04-30
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617