The objectives of this proposal are to identify and isolate those hormones and biochemical factors required for normal ovarian development in mosquitoes. Once this goal is attained studies using in vivo and in vitro techniques will be used to elucidate not only the physiologically normal temporal sequence of these hormones but also their modes of action at the molecular level. It is expected that knowledge derived from this study will allow the intelligent and rational development of specific agents which will interfere with the normal reproductive cycle of these important vectors. Application of such agents could lead to more effective specific mosquito population control. Furthermore, the insights gained with mosquitoes as a model may be applicable to other insects and thus have broad biological and practical consequences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI010707-14
Application #
3124779
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1978-03-01
Project End
1987-02-28
Budget Start
1985-03-01
Budget End
1987-02-28
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Notre Dame
Department
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556