Work for the coming year will deal, for the most part, with (a) relating changes in the biological activity of lipoteichoic acid from a group B streptococcal clinical isolate with changes in its lipid moiety using human cell lines in tissue culture as the assay system, (b) quantitatively comparing the types and amounts of teichoic acid being excreted by Streptococcus pyogenes, a group B streptococcus and their respective L-forms and determining at what stage of growth this excretion becomes most pronounced for each of these organisms and (c) determining if collagen synthesis in animal cells is directly affected by streptococcal lipoteichoic acid and, if so, whether this occurs before any morphological change becomes apparent in such cells.
| Miyazaki, S; Leon, O; Panos, C (1988) Adherence of Streptococcus agalactiae to synchronously growing human cell monolayers without lipoteichoic acid involvement. Infect Immun 56:505-12 |
| Leon, O; Panos, C (1988) Differences in penicillin-binding proteins of Streptococcus pyogenes and two derived, stabilized L forms. J Bacteriol 170:4775-83 |
| Leon, O; Panos, C (1987) An electron microscope study of kidney basement membrane changes in the mouse by lipoteichoic acid from Streptococcus pyogenes. Can J Microbiol 33:709-17 |
| Leon, O; Panos, C (1985) Effect of streptococcal lipoteichoic acid on prolyl hydroxylase activity as related to collagen formation in mouse fibroblast monolayers. Infect Immun 50:745-52 |
