Abstract

This project continues to investigate the immune responses, particularly the thymus-dependent phenomenon of contact hypersensitivity. We will continue to investigate the mechanisms of the development of contact sensitization. We will follow up on our studies of the induction of specific immunologic tolerance and its mechanisms. These include suppressor cells and clone inhibition and the relation between them.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI012685-20
Application #
3125251
Study Section
Immunobiology Study Section (IMB)
Project Start
1978-01-01
Project End
1987-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Holda, J H; Maier, T; Claman, H N (1990) IL-3, IL-4, and IL-6 enhance IFN-gamma-dependent bone marrow natural suppressor activity. Cell Immunol 125:459-68
Maier, T; Holda, J H; Claman, H N (1989) Murine natural suppressor cells in the newborn, in bone marrow, and after cyclophosphamide. Genetic variations and dependence on IFN-gamma. J Immunol 143:491-8
Choi, K L; Maier, T; Holda, J H et al. (1988) Suppression of cytotoxic T-cell generation by natural suppressor cells from mice with GVHD is partially reversed by indomethacin. Cell Immunol 112:271-8
Claman, H N; Holda, J H; Maier, T et al. (1988) Chronic graft-vs.-host disease: changes in natural suppressor cells and mast cells. Isr J Med Sci 24:367-9, 371
Giorno, R; Choi, K L; Katz, H R et al. (1987) Monoclonal antibody analysis of skin in chronic murine graft vs host disease produced across minor histocompatibility barriers. Cell Immunol 106:76-87
Maier, T; Holda, J H (1987) Natural suppressor (NS) activity from murine neonatal spleen is responsive to IFN-gamma. J Immunol 138:4075-84
Mekori, Y A; Claman, H N (1986) Desensitization of experimental contact sensitivity. J Allergy Clin Immunol 78:1073-81
Mustain, E L; Claman, H N; Moorhead, J W (1986) Antibody-mediated regulation of T cell responses. I. Characterization of a monoclonal antibody which specifically regulates contact hypersensitivity to DNFB in BALB/c mice. J Immunol 136:4372-8
Holda, J H; Maier, T; Claman, H N (1986) Natural suppressor activity in graft-vs-host spleen and normal bone marrow is augmented by IL 2 and interferon-gamma. J Immunol 137:3538-43
Mekori, Y A; Claman, H N (1986) Desensitization of contact allergy to DNFB in mice. III. Characteristics of immediate desensitization induced by haptenated spleen cells. Cell Immunol 98:279-88

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