Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI012717-16
Application #
2059918
Study Section
Virology Study Section (VR)
Project Start
1978-06-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Johnson, R A; Huong, S M; Huang, E S (2000) Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38. J Virol 74:1158-67
Yurochko, A D; Huang, E S (1999) Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression. J Immunol 162:4806-16
Yurochko, A D; Huong, S M; Huang, E S (1999) Identification of human cytomegalovirus target sequences in the human immunodeficiency virus long terminal repeat. Potential role of IE2-86 binding to sequences between -120 and -20 in promoter transactivation. J Hum Virol 2:81-90
Johnson, R A; Huong, S M; Huang, E S (1999) Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H - imidazole on HCMV DNA replication and permissive infection. Antiviral Res 41:101-11
Johnson, R A; Yurochko, A D; Poma, E E et al. (1999) Domain mapping of the human cytomegalovirus IE1-72 and cellular p107 protein-protein interaction and the possible functional consequences. J Gen Virol 80 ( Pt 5):1293-303
Yurochko, A D; Hwang, E S; Rasmussen, L et al. (1997) The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection. J Virol 71:5051-9
Yurochko, A D; Mayo, M W; Poma, E E et al. (1997) Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters. J Virol 71:4638-48
Poma, E E; Kowalik, T F; Zhu, L et al. (1996) The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J Virol 70:7867-77
Yurochko, A D; Kowalik, T F; Huong, S M et al. (1995) Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters. J Virol 69:5391-400
Wing, B A; Huang, E S (1995) Analysis and mapping of a family of 3'-coterminal transcripts containing coding sequences for human cytomegalovirus open reading frames UL93 through UL99. J Virol 69:1521-31

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