Abstract

Using reovirus recombinants, we plan to determine the viral gene responsible for a series of viral host interactions including: immunity, toxicity, entry. In addition, viral enzymatic functions will be analyzed as well as initiating an RNA sequencing of the viral hemagglutinin.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI013178-10
Application #
3125412
Study Section
Virology Study Section (VR)
Project Start
1976-06-30
Project End
1986-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Derrien, Muriel; Hooper, Jay W; Fields, Bernard N (2003) The M2 gene segment is involved in the capacity of reovirus type 3Abney to induce the oily fur syndrome in neonatal mice, a S1 gene segment-associated phenotype. Virology 305:25-30
Derrien, M; Fields, B N (2000) Anti-interleukin-3 and anti-nerve growth factor increase neonatal mice survival to reovirus type 3 clone 9 per oral challenge. J Neuroimmunol 110:209-13
Derrien, M; Fields, B N (1999) Reovirus type 3 clone 9 increases interleukin-1alpha level in the brain of neonatal, but not adult, mice. Virology 257:35-44
Dryden, K A; Farsetta, D L; Wang, G et al. (1998) Internal/structures containing transcriptase-related proteins in top component particles of mammalian orthoreovirus. Virology 245:33-46
Luongo, C L; Dryden, K A; Farsetta, D L et al. (1997) Localization of a C-terminal region of lambda2 protein in reovirus cores. J Virol 71:8035-40
Rozinov, M N; Fields, B N (1996) Evidence for phenotypic mixing with reovirus in cell culture. Virology 215:207-10
Rozinov, M N; Fields, B N (1996) Interference of reovirus strains occurs between the stages of uncoating and dsRNA accumulation. J Gen Virol 77 ( Pt 7):1425-9
Wilson, G A; Morrison, L A; Fields, B N (1994) Association of the reovirus S1 gene with serotype 3-induced biliary atresia in mice. J Virol 68:6458-65
Dermody, T S; Nibert, M L; Wetzel, J D et al. (1993) Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J Virol 67:2055-63
Lucia-Jandris, P; Hooper, J W; Fields, B N (1993) Reovirus M2 gene is associated with chromium release from mouse L cells. J Virol 67:5339-45

Showing the most recent 10 out of 25 publications