The overall objectives of this project are to investigate cellular and genetic mechanisms in the induction and regulation of murine cell-mediated immune responses to alloantigens in vitro. The work is focused on the function of alloantigen-activated murine suppressor T cells in the control of mixed leukocyte reactions and the generation of cytotoxic T lymphocytes. Cell surface features of T lymphocytes producing and responding to molecules elaborated in the regulation of in vitro cell-mediated immune responses will be studied in detail. An additional aspect of this work is to identify and characterize genetic loci that can induce such responses both within and adjacent to but outside the H-2 complex. Cell-mediated immune responses to antigens encoded in the Qa-T1a region are of particular interest. Regulatory interactions between cellular subpopulations involved both in the induction and regulation of these responses will be explored. The relationship of antigens recognized serologically and by T cell-mediated cytotoxicity will also be investigated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI013810-09
Application #
3125559
Study Section
Experimental Immunology Study Section (EI)
Project Start
1977-02-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Rodgers, J R; Smith 3rd, R; Huston, M M et al. (1986) Maternally transmitted antigen. Adv Immunol 38:313-59
Beckwith, M; Arhelger, C; Rich, S (1985) A soluble T cell suppressor factor for the mixed leukocyte response (MLR-TsF). Methods Enzymol 116:416-27
Smith 3rd, R; Rich, R R (1985) Polymorphism and tissue distribution of maternally transmitted antigen defined by cytotoxic T lymphocyte lines. J Immunol 134:2191-7