Abstract

These studies propose studying group B streptococcal (GBS) sepsis, meningitis, and pneumonia in animals, to examine cellular and humoral responses to GBS antigens, and to study factors which favor establishment and maintenance of chronic GBS carriage at mucosal sites as well as approaches for eradication. Results will be evaluated for their possible application to prevention and treatment of group B streptococcal infections.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI013926-09
Application #
3125577
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1977-07-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Suvorov, A N; Flores, A E; Ferrieri, P (1997) Cloning of the glutamine synthetase gene from group B streptococci. Infect Immun 65:191-6
Fasola, E L; Flores, A E; Ferrieri, P (1996) Immune responses to the R4 protein antigen of group B streptococci and its relationship to other streptococcal R4 proteins. Clin Diagn Lab Immunol 3:321-5
Chmouryguina, I; Suvorov, A; Ferrieri, P et al. (1996) Conservation of the C5a peptidase genes in group A and B streptococci. Infect Immun 64:2387-90
Flores, A E; Nelson, J A; Wu, X Y et al. (1993) Antibody profiles to the group B streptococcal beta antigen in maternal and infant paired sera. APMIS 101:41-9
Cleary, P P; Handley, J; Suvorov, A N et al. (1992) Similarity between the group B and A streptococcal C5a peptidase genes. Infect Immun 60:4239-44
Belani, K; Schlievert, P M; Kaplan, E L et al. (1991) Association of exotoxin-producing group A streptococci and severe disease in children. Pediatr Infect Dis J 10:351-4
Ferrieri, P (1990) Neonatal susceptibility and immunity to major bacterial pathogens. Rev Infect Dis 12 Suppl 4:S394-400
Flores, A E; Ferrieri, P (1989) Molecular species of R-protein antigens produced by clinical isolates of group B streptococci. J Clin Microbiol 27:1050-4
Ferrieri, P (1988) Surface-localized protein antigens of group B streptococci. Rev Infect Dis 10 Suppl 2:S363-6
Halperin, S A; Ferrieri, P; Gray, E D et al. (1987) Antibody response to bacteriophage hyaluronidase in acute glomerulonephritis after group A streptococcal infection. J Infect Dis 155:253-61

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