Abstract

This application is to continue studies of the human immune response to the group B streptococci (GBS), a major cause of infection in newborn infants, in order to determine ways in which immunity may influence infection with and carriage of GBS. An enzyme-linked-immunosorbent assay and other assays will be used to quantitate antibody of the various immunoglobulin subclasses to purified type- and group-specific carbohydrates of GBS. Sera from pregnant patients, their infants, healthy adults, infected infants, adult recipients of group B streptococcal vaccines, and healthy infants and children of different ages will be studied. The biological activity of whole human serum and purified immunoglobulin fractions will be compared in newborn rats infected with GBS. Antibody in breast milk and other secretions will be studied to define the secretory immune response to GBS carriage and to determine any relationships between secretory immunity and carriage of GBS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI014827-08
Application #
3125900
Study Section
(SSS)
Project Start
1979-01-01
Project End
1988-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Los Angeles County Harbor-UCLA Medical Center
Department
Type
DUNS #
City
Torrance
State
CA
Country
United States
Zip Code
90509

  Publications

Anthony, B F; Concepcion, N F; Puentes, S M et al. (1990) Nonimmune binding of human immunoglobulin A to type II group B streptococci. Infect Immun 58:1789-95
Payne, N R; Concepcion, N F; Anthony, B F (1990) Opsonic effect of jacalin and human immunoglobulin A on type II group B streptococci. Infect Immun 58:3663-70
Anthony, B F; Concepcion, N F (1989) Opsonic activity of human IgG and IgM antibody for type III group B streptococci. Pediatr Res 26:383-7
Kim, K S; Wass, C A; Hong, J K et al. (1988) Demonstration of opsonic and protective activity of human cord sera against type III group B streptococcus that are independent of type-specific antibody. Pediatr Res 24:628-32
Marxmiller, J N; Gray, B M; Anthony, B F (1987) IgA antibody to group specific polysaccharide in secretions of carriers and noncarriers of group B streptococci. Adv Exp Med Biol 216B:989-94
Kim, K S; Kang, J H; Concepcion, N F et al. (1986) Relative functional activity of purified human immunoglobulin G against a type III group B streptococcal strain. Infect Immun 52:908-10
Kim, K S; Wass, C A; Kang, J H et al. (1986) Functional activities of various preparations of human intravenous immunoglobulin against type III group B Streptococcus. J Infect Dis 153:1092-7
Anthony, B F; Concepcion, N F; Concepcion, K F (1985) Human antibody to the group-specific polysaccharide of group B Streptococcus. J Infect Dis 151:221-6
Anthony, B F (1985) Epidemiology of GBS in man. Antibiot Chemother 35:10-6