Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI014885-19
Application #
2060122
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1978-04-01
Project End
1998-02-28
Budget Start
1996-04-01
Budget End
1998-02-28
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Associated University-Brookhaven National Lab
Department
Type
DUNS #
City
Upton
State
NY
Country
United States
Zip Code
11973
Lacks, S A; Ayalew, S; de la Campa, A G et al. (2000) Regulation of competence for genetic transformation in Streptococcus pneumoniae: expression of dpnA, a late competence gene encoding a DNA methyltransferase of the DpnII restriction system. Mol Microbiol 35:1089-98
Zhang, Y B; Ayalew, S; Lacks, S A (1997) The rnhB gene encoding RNase HII of Streptococcus pneumoniae and evidence of conserved motifs in eucaryotic genes. J Bacteriol 179:3828-36
Lacks, S A (1997) Cloning and expression of pneumococcal genes in Streptococcus pneumoniae. Microb Drug Resist 3:327-37
Kumaresan, K R; Springhorn, S S; Lacks, S A (1995) Lethal and mutagenic actions of N-methyl-N'-nitro-N-nitrosoguanidine potentiated by oxidized glutathione, a seemingly harmless substance in the cellular environment. J Bacteriol 177:3641-6
Lacks, S A; Greenberg, B; Lopez, P (1995) A cluster of four genes encoding enzymes for five steps in the folate biosynthetic pathway of Streptococcus pneumoniae. J Bacteriol 177:66-74
Diaz, A; Lacks, S A; Lopez, P (1994) Multiple roles for DNA polymerase I in establishment and replication of the promiscuous plasmid pLS1. Mol Microbiol 14:773-83
Lopez, P; Lacks, S A (1993) A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities. J Bacteriol 175:2214-20
Diaz, A; Pons, M E; Lacks, S A et al. (1992) Streptococcus pneumoniae DNA polymerase I lacks 3'-to-5' exonuclease activity: localization of the 5'-to-3' exonucleolytic domain. J Bacteriol 174:2014-24
Diaz, A; Lacks, S A; Lopez, P (1992) The 5' to 3' exonuclease activity of DNA polymerase I is essential for Streptococcus pneumoniae. Mol Microbiol 6:3009-19
Chen, J D; Lacks, S A (1991) Role of uracil-DNA glycosylase in mutation avoidance by Streptococcus pneumoniae. J Bacteriol 173:283-90

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