Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI017151-06S1
Application #
3127000
Study Section
(SSS)
Project Start
1980-07-01
Project End
1988-02-29
Budget Start
1987-12-01
Budget End
1988-02-29
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Sypek, J P; Jacobson, S; Vorys, A et al. (1993) Comparison of gamma interferon, tumor necrosis factor, and direct cell contact in activation of antimycobacterial defense in murine macrophages. Infect Immun 61:3901-6
Birkland, T P; Sypek, J P; Wyler, D J (1992) Soluble TNF and membrane TNF expressed on CD4+ T lymphocytes differ in their ability to activate macrophage antileishmanial defense. J Leukoc Biol 51:296-9
Sypek, J P; Matzilevich, M M; Wyler, D J (1991) Th2 lymphocyte clone can activate macrophage antileishmanial defense by a lymphokine-independent mechanism in vitro and can augment parasite attrition in vivo. Cell Immunol 133:178-86
Sypek, J P; Wyler, D J (1991) Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane. J Exp Med 174:755-9
Sypek, J P; Wyler, D J (1990) T-cell hybridomas reveal two distinct mechanisms of antileishmanial defense. Infect Immun 58:1146-52
Sypek, J P; Wyler, D J (1988) Susceptibility of lymphokine-resistant Leishmania to cell contact-mediated macrophage activation. J Infect Dis 158:392-7
Wyler, D J (1987) Fibronectin in parasitic diseases. Rev Infect Dis 9 Suppl 4:S391-9
North, T W; Wyler, D J (1987) DNA synthesis in promastigotes of Leishmania major and L. donovani. Mol Biochem Parasitol 22:215-21
Wyler, D J; Beller, D I; Sypek, J P (1987) Macrophage activation for antileishmanial defense by an apparently novel mechanism. J Immunol 138:1246-9
Crawford, G D; Wyler, D J; Dinarello, C A (1985) Parasite-monocyte interactions in human leishmaniasis: production of interleukin-1 in vitro. J Infect Dis 152:315-22

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