Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI017653-12
Application #
2060546
Study Section
Metabolism Study Section (MET)
Project Start
1981-05-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Makar, R S; Lipsky, P E; Cuthbert, J A (1998) Sterol-independent, sterol response element-dependent, regulation of low density lipoprotein receptor gene expression. J Lipid Res 39:1647-54
Cuthbert, J A; Lipsky, P E (1995) Suppression of the proliferation of Ras-transformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism. Cancer Res 55:1732-40
Makar, R S; Lipsky, P E; Cuthbert, J A (1994) Non-sterol regulation of low density lipoprotein receptor gene expression in T cells. J Lipid Res 35:1888-95
Spady, D K; Cuthbert, J A (1992) Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor. J Biol Chem 267:5584-91
Cuthbert, J A; Lipsky, P E (1991) A product of mevalonate proximal to isoprenoids is the source of both a necessary growth factor and an inhibitor of cell proliferation. Trans Assoc Am Physicians 104:97-106
Cuthbert, J A; Lipsky, P E (1991) Negative regulation of cell proliferation by mevalonate or one of the mevalonate phosphates. J Biol Chem 266:17966-71
Cuthbert, J A; Lipsky, P E (1990) Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation. J Biol Chem 265:18568-75
Cuthbert, J A; Lipsky, P E (1990) Tissue-specific regulation of low density lipoprotein receptor gene expression. Trans Assoc Am Physicians 103:271-80
Cuthbert, J A; Lipsky, P E (1990) Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes. J Lipid Res 31:2067-78
Cuthbert, J A; Lipsky, P E (1989) Identification of low density lipoprotein receptor abnormalities by assaying functional receptors on proliferating lymphocytes. Arteriosclerosis 9:I43-9

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