This grant will continue a research program to investigate the fundamental chemistry of recently discovered, bioloically active natural products. Our plans include two major target areas for study. Firstly, our continuing efforts for synthesis of the pseudomonic acids A, B, and C are nearing completion. These studies have led to the development of efficient strategies for prepartion of L-carbohydrates and stereochemically complex oxacyclic systems. The major emphasis of this proposal describes strategies for highly convergent, enantiospecific investigations of the chemistry of the lankacidins. These unique macrocyclic metabolites display considerable antitumor activity against L1210 leukemia, B16 melanoma, and solid lymphosarcoma, in vivo, and are only weakly toxic in mice. They also show strong atimicrobial activities, principally against Gram-positive bacteria, including some strains of clinically resistant isolates.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI017674-06
Application #
3127376
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-04-01
Project End
1988-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Indiana University Bloomington
Department
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47402