Abstract

There is an enlarging spectrum of tick-transmitted spirochetal diseases. Lyme disease, a relatively new and clinically important syndrome is caused by Borrelia burgdorferi (a new species) which is transmitted primarily by the bite of Ixodes ticks. The number of human cases and the geographical area in which the disease is present is increasing in number and size, respectively. Recent reports indicate that the North American Borrelia, B. hermsii can cause chronic infection lasting 10 years with episodes of exacerbation.
The specific aims of this proposal are: 1) Conduct genetic studies of the Borrelia 2) Determine optimal conditions for the isolation of the relapsing fever borrelia 3) Define host and bacterial factors involved in pathogenesis of borreliosis 4) Determine the in vitro and in vivo antibotic sensitivity of the relapsing fever borreliae and 5) Development of test for serodiagnosis of borreleosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018153-06
Application #
3127727
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1982-09-30
Project End
1988-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Anderson, J F; Magnarelli, L A; LeFebvre, R B et al. (1989) Antigenically variable Borrelia burgdorferi isolated from cottontail rabbits and Ixodes dentatus in rural and urban areas. J Clin Microbiol 27:13-20
Anderson, J F; Johnson, R C; Magnarelli, L A et al. (1987) New infectious spirochete isolated from short-tailed shrews and white-footed mice. J Clin Microbiol 25:1490-4
Anderson, J F; Johnson, R C; Magnarelli, L A (1987) Seasonal prevalence of Borrelia burgdorferi in natural populations of white-footed mice, Peromyscus leucopus. J Clin Microbiol 25:1564-6
Anderson, J F; Johnson, R C; Magnarelli, L A et al. (1987) Prevalence of Borrelia burgdorferi and Babesia microti in mice on islands inhabited by white-tailed deer. Appl Environ Microbiol 53:892-4
Anderson, J F; Johnson, R C; Magnarelli, L A et al. (1986) Peromyscus leucopus and Microtus pennsylvanicus simultaneously infected with Borrelia burgdorferi and Babesia microti. J Clin Microbiol 23:135-7
Anderson, J F; Johnson, R C; Magnarelli, L A et al. (1986) Culturing Borrelia burgdorferi from spleen and kidney tissues of wild-caught white-footed mice, Peromyscus leucopus. Zentralbl Bakteriol Mikrobiol Hyg A 263:34-9
Hyde, F W; Johnson, R C (1986) Genetic analysis of Borrelia. Zentralbl Bakteriol Mikrobiol Hyg A 263:119-22
Johnson, R C; Kodner, C L; Russell, M E (1986) Vaccination of hamsters against experimental infection with Borrelia burgdorferi. Zentralbl Bakteriol Mikrobiol Hyg A 263:45-8
Duray, P H; Johnson, R C (1986) The histopathology of experimentally infected hamsters with the Lyme disease spirochete, Borrelia burgdorferi. Proc Soc Exp Biol Med 181:263-9
Loken, K I; Wu, C C; Johnson, R C et al. (1985) Isolation of the Lyme disease spirochete from mammals in Minnesota. Proc Soc Exp Biol Med 179:300-2

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