Abstract

A controlled double blind study of immunotherapy of cat induced asthma in comparison with placebos will be carried out. Responses will be evaluated by clinical symptoms and airway responses to aerosol of cat pelt extract, methacholine and exposure to live cats. Immunological responses will be assessed by measurement of basophil histamine release, IgG antibodies, IgE antibodies to cat pelt extract and by assay for circulating immune complexes and for pemphigus antibodies. Allergens of cat pelt extracts will be identified and purified.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018374-06
Application #
3127871
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1982-04-01
Project End
1990-08-31
Budget Start
1988-09-01
Budget End
1990-08-31
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Van Metre Jr, T E; Marsh, D G; Adkinson Jr, N F et al. (1989) Immunotherapy decreases skin sensitivity to cat extract. J Allergy Clin Immunol 83:888-99
Van Metre Jr, T E; Marsh, D G; Adkinson Jr, N F et al. (1988) Immunotherapy for cat asthma. J Allergy Clin Immunol 82:1055-68
Van Metre Jr, T E (1987) Unproven procedures for diagnosis and treatment of food allergy. N Engl Reg Allergy Proc 8:17-21
Van Metre Jr, T E; Marsh, D G; Adkinson Jr, N F et al. (1986) Dose of cat (Felis domesticus) allergen 1 (Fel d 1) that induces asthma. J Allergy Clin Immunol 78:62-75