The objective is to improve the effectiveness of measles and tetanus vaccines in developing countries, thereby diminishing mortality and debility there, reducing measles virus importation to the USA and learning more about the identity of the immunoglobulin which protect against measles and the factors which control their transport to the fetus. Specifically we will: 1. Identify the factors(s) which determine the age at which a child becomes susceptible to measles and responsive to vaccine. 2. Study the relative roles in protection from disease of immunologlobulin idiotypes directed toward the four major structural proteins of measles virus. 3. Quantitate the response of the human adult to repeated doses of tetanus toxiod and to set up practical guidelines for determination of vaccine needs in diverse populations. 4. Seek to learn more about the mechanism of transplacental movement of immunoglobulins in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018502-05
Application #
3127996
Study Section
Virology Study Section (VR)
Project Start
1982-04-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Varela, L R; Black, F L; Mendizabal-Morris, C A (1985) Tetanus antitoxin titers in women of childbearing age from nine diverse populations. J Infect Dis 151:850-3