Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI018615-03S1
Application #
3128043
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1982-05-01
Project End
1985-06-30
Budget Start
1985-05-01
Budget End
1985-06-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Chan, S C; Brown, M A; Willcox, T M et al. (1996) Abnormal IL-4 gene expression by atopic dermatitis T lymphocytes is reflected in altered nuclear protein interactions with IL-4 transcriptional regulatory element. J Invest Dermatol 106:1131-6
Hanifin, J M; Chan, S C; Cheng, J B et al. (1996) Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol 107:51-6
Toshitani, A; Ansel, J C; Chan, S C et al. (1993) Increased interleukin 6 production by T cells derived from patients with atopic dermatitis. J Invest Dermatol 100:299-304
Chan, S C; Kim, J W; Henderson Jr, W R et al. (1993) Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis. J Immunol 151:3345-52
Chan, S C; Reifsnyder, D; Beavo, J A et al. (1993) Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J Allergy Clin Immunol 91:1179-88
Li, S H; Chan, S C; Kramer, S M et al. (1993) Modulation of leukocyte cyclic AMP phosphodiesterase activity by recombinant interferon-gamma: evidence for a differential effect on atopic monocytes. J Interferon Res 13:197-202
Chan, S C; Li, S H; Hanifin, J M (1993) Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol 100:681-4
Chan, S C; Hanifin, J M (1993) Differential inhibitor effects on cyclic adenosine monophosphate-phosphodiesterase isoforms in atopic and normal leukocytes. J Lab Clin Med 121:44-51
Li, S H; Chan, S C; Toshitani, A et al. (1992) Synergistic effects of interleukin 4 and interferon-gamma on monocyte phosphodiesterase activity. J Invest Dermatol 99:65-70
Hanifin, J M; Lloyd, R; Okubo, K et al. (1992) Relationship between increased cyclic AMP-phosphodiesterase activity and abnormal adenylyl cyclase regulation in leukocytes from patients with atopic dermatitis. J Invest Dermatol 98:100S-105S

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